Isocorrole-Loaded Polymer Nanoparticles for Photothermal Therapy under 980 nm Light Excitation
| Author(s) | Marek, Maximilian R. J. | |
| Author(s) | Pham, Trong-Nhan | |
| Author(s) | Wang, Jianxin | |
| Author(s) | Cai, Qiuqi | |
| Author(s) | Yap, Glenn P. A. | |
| Author(s) | Day, Emily S. | |
| Author(s) | Rosenthal, Joel | |
| Date Accessioned | 2023-10-11T18:20:40Z | |
| Date Available | 2023-10-11T18:20:40Z | |
| Publication Date | 2022-10-18 | |
| Description | This article was originally published in ACS Omega. The version of record is available at: https://doi.org/10.1021/acsomega.2c04723. Copyright © 2022 The Authors. Published by American Chemical Society. | |
| Abstract | Photothermal therapy (PTT) is a promising treatment option for diseases, including cancer, arthritis, and periodontitis. Typical photothermal agents (PTAs) absorb light in the near-infrared (NIR)-I region of 650–900 nm with a predominant focus around 800 nm, as these wavelengths are minimally absorbed by water and blood in the tissue. Recently, interest has grown in developing nanomaterials that offer more efficient photothermal conversion and that can be excited by light close to or within the NIR-II window of 1000–1700 nm, which offers less absorption by melanin. Herein, we report on the development of 5,5-diphenyl isocorrole (5-DPIC) complexes containing either Zn(II) or Pd(II) (Zn[5-DPIC] and Pd[5-DPIC], respectively) that absorb strongly across the 850–1000 nm window. We also show that poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with these designer isocorroles exhibit low toxicity toward triple-negative breast cancer (TNBC) cells in the dark but enable efficient heat production and photothermal cell ablation upon excitation with 980 nm light. These materials represent an exciting new platform for 980 nm activated PTT and demonstrate the potential for designer isocorroles to serve as effective PTAs. | |
| Sponsor | This research was supported by the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) under Award R35GM119659 (ESD) and by a grant from the Delaware Bioscience Center for Advanced Technology (J.R., E.S.D.). Portions of the isocorrole synthetic work were supported through the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences EPSCoR and Catalysis programs under Award Number DESC-0001234 (J.R.). Microscopy access was supported by grants from the NIH-NIGMS (P20-GM103446), the National Science Foundation (IIA-1301765), and the State of Delaware. X-ray diffraction data collection was supported by the National Institutes of Health (S10-OD026896A). | |
| Citation | Marek, Maximilian R. J., Trong-Nhan Pham, Jianxin Wang, Qiuqi Cai, Glenn P. A. Yap, Emily S. Day, and Joel Rosenthal. “Isocorrole-Loaded Polymer Nanoparticles for Photothermal Therapy under 980 Nm Light Excitation.” ACS Omega 7, no. 41 (October 18, 2022): 36653–62. https://doi.org/10.1021/acsomega.2c04723. | |
| ISSN | 2470-1343 | |
| URL | https://udspace.udel.edu/handle/19716/33533 | |
| Language | en_US | |
| Publisher | ACS Omega | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| Keywords | copolymers | |
| Keywords | electromagnetic radiation | |
| Keywords | irradiation | |
| Keywords | light | |
| Keywords | light absorption | |
| Keywords | good health and well-being | |
| Title | Isocorrole-Loaded Polymer Nanoparticles for Photothermal Therapy under 980 nm Light Excitation | |
| Type | Article |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Isocorrole-Loaded Polymer Nanoparticles for Photothermal Therapy.pdf
- Size:
- 6.15 MB
- Format:
- Adobe Portable Document Format
- Description:
- Main article
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 2.22 KB
- Format:
- Item-specific license agreed upon to submission
- Description: