Isocorrole-Loaded Polymer Nanoparticles for Photothermal Therapy under 980 nm Light Excitation
Date
2022-10-18
Authors
Marek, Maximilian R. J.
Pham, Trong-Nhan
Wang, Jianxin
Cai, Qiuqi
Yap, Glenn P. A.
Day, Emily S.
Rosenthal, Joel
Journal Title
Journal ISSN
Volume Title
Publisher
ACS Omega
Abstract
Photothermal therapy (PTT) is a promising treatment option for diseases, including cancer, arthritis, and periodontitis. Typical photothermal agents (PTAs) absorb light in the near-infrared (NIR)-I region of 650–900 nm with a predominant focus around 800 nm, as these wavelengths are minimally absorbed by water and blood in the tissue. Recently, interest has grown in developing nanomaterials that offer more efficient photothermal conversion and that can be excited by light close to or within the NIR-II window of 1000–1700 nm, which offers less absorption by melanin. Herein, we report on the development of 5,5-diphenyl isocorrole (5-DPIC) complexes containing either Zn(II) or Pd(II) (Zn[5-DPIC] and Pd[5-DPIC], respectively) that absorb strongly across the 850–1000 nm window. We also show that poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with these designer isocorroles exhibit low toxicity toward triple-negative breast cancer (TNBC) cells in the dark but enable efficient heat production and photothermal cell ablation upon excitation with 980 nm light. These materials represent an exciting new platform for 980 nm activated PTT and demonstrate the potential for designer isocorroles to serve as effective PTAs.
Description
This article was originally published in ACS Omega. The version of record is available at: https://doi.org/10.1021/acsomega.2c04723. Copyright © 2022 The Authors. Published by American Chemical Society.
Keywords
copolymers, electromagnetic radiation, irradiation, light, light absorption, good health and well-being
Citation
Marek, Maximilian R. J., Trong-Nhan Pham, Jianxin Wang, Qiuqi Cai, Glenn P. A. Yap, Emily S. Day, and Joel Rosenthal. “Isocorrole-Loaded Polymer Nanoparticles for Photothermal Therapy under 980 Nm Light Excitation.” ACS Omega 7, no. 41 (October 18, 2022): 36653–62. https://doi.org/10.1021/acsomega.2c04723.