Institutional Repository

The UDSpace Institutional Repository collects and disseminates research material from the University of Delaware.

Faculty, staff, and graduate students who want their research material hosted in UDSpace should contact the University of Delaware Insitutional Repository team at openaccess@udel.edu.
Faculty may use UDSpace to fulfill the University of Delaware Faculty Senate Open Access Resolution, and in many cases may use it to fulfill open access requirements from grant funding agencies.
Departments can use UDSpace to publish or distribute their working papers, technical reports, or other research material.
UDSpace also includes all doctoral dissertations from winter 2014 forward, and all master's theses from fall 2009 forward.

To learn more about UDSpace, and how you can make your research openly accessible to the public, visit our UDSpace Information website.

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Recent Submissions

2026, 21th Issue, part 2
(Newark, Del.: Chesapeake Pub. Corp., 2026-06-12) Newark post
2026, 21th Issue, part 1
(Newark, Del.: Chesapeake Pub. Corp., 2026-06-12) Newark post
Complete genome sequences of metal-oxidizing bacteria Leptothrix mechoopdaensis BB-3 and BB-4
(Geomicrobiology Journal, 2026-05-06) Fleming, Emily J; McIntyre, Abigail; Tothero, Gracee K; Zimmer, Joyce A; Keffer, Jessica L; Pierce, Lydia N; Beilsmith, Kathleen R; Wilton, Rosemarie; Chan, Clara S; Anantharaman, Karthik
Leptothrix mechoopdaensis BB-3 and BB-4 are metal-oxidizing, sheathed, filamentous bacteria that were isolated from a woodland iron seep near Centerville, Chico, CA, USA. Here, we report a closed circular genome sequence for each strain, assembled from reads sequenced on an Oxford Nanopore FLO-MIN114 flow cell.
Yearlong Genre-Based Writing Instruction in the Middle Grades: An Investigation of Writing and Self-Efficacy
(Education Sciences, 2026-04-10) Philippakos, Zoi A. Traga; Rocconi, Louis; Macarthur, Charles
This study investigated associations between a yearlong genre-based writing curriculum and students’ writing and self-efficacy outcomes. The curriculum had two stages: first, teaching genre elements without requiring use of sources and citations, and then integrating information from readings. Participants included 340 students and 3 teachers across 6th to 8th grades in a rural Title I middle school. Using a quasi-experimental, one-group pretest–posttest design with repeated measures, analysis showed significant improvements in writing quality across argumentative, compare-and-contrast, and narrative genres for all grades. Improvement patterns varied by grade and genre; self-efficacy and affect results were mixed—gains appeared in specific areas, but overall, self-efficacy decreased when reading was incorporated. Findings suggest the yearlong approach enhances writing quality but may require additional strategies to maintain student motivation.
Isolation and characterization of probiotic candidates with antimicrobial and barrier-protective properties
(Scientific Reports, 2026-06-03) Joseph, Jiddu; Boby, Sanya; Zhu, Zhaoyan; Mooyottu, Shankumar; Vinayamohan, Poonam Gopika; Pellissery, Abraham Joseph; Li, Yihang; Muyyarikkandy, Muhammed Shafeekh
Antimicrobial resistance (AMR) in pathogens such as multidrug-resistant Salmonella Typhimurium and extended-spectrum β-lactamase (ESBL) Escherichia coli poses a growing threat to human, animal, and environmental health, yet effective non-antibiotic mitigation strategies remain limited. Here, we report the isolation and comprehensive characterization of three lactic acid bacteria from homemade cottage cheese, including Leuconostoc pseudomesenteroides MLS3, Lactococcus lactis MLS12, and Leuconostoc lactis MLS22 as next-generation probiotic candidates targeting these AMR pathogens. Whole-genome sequencing confirmed compact genomes (1.7–2.5 Mb) free of transferable resistance determinants and enriched in secondary metabolite biosynthetic clusters. All three strains survived gastrointestinal challenge conditions (≥ 6 log CFU/mL at pH 1.5, 2% bile salts, and 100 µg/mL lysozyme), exhibited strong mucosal adhesion parameters (auto-aggregation 30–33%, surface hydrophobicity 20–49%), and co-aggregated efficiently with both pathogens (27–64%). Live co-cultures and cell-free supernatants significantly inhibited S. Typhimurium and ESBL E. coli within 24 h, with electron microscopy revealing probiotic-induced structural disruption of pathogen cell integrity. Probiotic pretreatment extended Caenorhabditis elegans lifespan under Salmonella challenge (P < 0.001), and cell-free supernatants attenuated LPS-induced epithelial barrier permeability in chicken enteroids (P < 0.05) without affecting baseline barrier function. Together, these findings demonstrate that MLS3, MLS12, and MLS22 combine genomic safety, gastrointestinal resilience, direct antimicrobial potency, and epithelial barrier protection, supporting their potential as effective probiotics for AMR-associated applications in food safety and gut health.