Intramolecular structure and dynamics in computationally designed peptide-based polymers displaying tunable chain stiffness
| Author(s) | Sinha, Nairiti J. | |
| Author(s) | Shi, Yi | |
| Author(s) | Kloxin, Christopher J. | |
| Author(s) | Saven, Jeffery G. | |
| Author(s) | Faraone, Antonio | |
| Author(s) | Jensen, Grethe V. | |
| Author(s) | Pochan, Darrin J | |
| Date Accessioned | 2022-01-19T20:32:28Z | |
| Date Available | 2022-01-19T20:32:28Z | |
| Publication Date | 2021-09-07 | |
| Description | This article was originally published in Physical Review Materials. The version of record is available at: https://doi.org/10.1103/PhysRevMaterials.5.095601 | en_US |
| Abstract | Polymers assembled using computationally designed coiled coil bundlemers display tunable stiffness via control of interbundlemer covalent connectivity as confirmed using small-angle neutron scattering. Neutron spin echo spectroscopy reveals that rigid rod polymers show a decay rate Γ∼Q2 (Q is the scattering vector) expected of straight cylinders. Semirigid polymers assembled using bundlemers linked via 4-armed organic linker show flexible segmental dynamics at mid-Q and Γ∼Q2 behavior at high Q. The results give insight into linker flexibility-dependent interbundlemer dynamics in the hybrid polymers. | en_US |
| Sponsor | This paper was prepared under Cooperative Agreement No. 370NANB17H302 from NIST, U.S. Department of Commerce. We acknowledge the support of the NIST, U.S. Department of Commerce in providing the neutron research facilities used in this paper. Access to v SANS was provided by the Center for High Resolution Neutron Scattering (CHRNS), a partnership between the NIST and the National Science Foundation under Agreement No. DMR-2010792. Support for peptide design, synthesis, purification, and bundlemer rod formation was provided by the Department of Energy, Office of Basic Energy Sciences, Biomolecular Materials Program under Grants No. DE-SC0019355 and No. DE-SC0019282. Samples were prepared for experiments at the NIST/IBBR Biomolecular Labeling Laboratory. The statements, findings, conclusions, and recommendations are those of the authors and do not necessarily reflect the view of NIST or the U.S. Department of Commerce. Certain commercial equipment, instruments, materials, suppliers, and software are identified in this paper to foster understanding. Such identification does not imply recommendation or endorsement by the NIST, nor does it imply that the materials or equipment identified are necessarily the best available for the purpose. | en_US |
| Citation | Sinha, Nairiti J., Yi Shi, Yao Tang, Christopher J. Kloxin, Jeffery G. Saven, Antonio Faraone, Grethe V. Jensen, and Darrin J. Pochan. 2021. “Intramolecular Structure and Dynamics in Computationally Designed Peptide-Based Polymers Displaying Tunable Chain Stiffness.” Phys. Rev. Materials 5 (9): 095601. https://doi.org/10.1103/PhysRevMaterials.5.095601. | en_US |
| ISSN | 2475-9953 | |
| URL | https://udspace.udel.edu/handle/19716/30046 | |
| Language | en_US | en_US |
| Publisher | Physical Review Materials | en_US |
| Title | Intramolecular structure and dynamics in computationally designed peptide-based polymers displaying tunable chain stiffness | en_US |
| Type | Article | en_US |
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