Peptide-based assembled nanostructures that can direct cellular responses

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Author(s)Huang, Haofu
Author(s)Kiick, Kristi
Date Accessioned2022-10-05T14:42:16Z
Date Available2022-10-05T14:42:16Z
Publication Date2022-09-29
DescriptionThis is an author-created, un-copyedited version of an article accepted for publication/publishedin Biomedical Materials. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1748-605X/ac92b5. This article will be embargoed until 09/29/2023.en_US
AbstractNatural originated materials have been well-studied over the past several decades owing to their higher biocompatibility compared to the traditional polymers. Peptides, consisting of amino acids, are among the most popular programmable building blocks, which is becoming a growing interest in nanobiotechnology. Structures assembled using those biomimetic peptides allow the exploration of chemical sequences beyond those been routinely used in biology. In this review, we discussed the most recent experimental discoveries on the peptide-based assembled nanostructures and their potential application at the cellular level such as drug delivery. In particular, we explored the fundamental principles of peptide self-assembly and the most recent development in improving their interactions with biological systems. We believe that as the fundamental knowledge of the peptide assemblies evolves, the more sophisticated and versatile nanostructures can be built, with promising biomedical applications.en_US
SponsorRelated work in the Authors' laboratories was funded in part by the National Institutes of Health (R21 AR069778A, RO1 AR067247, 1 P30 GM110758, and both 1 P30 GM103519 and 1 P20 GM104316 for instrument resources) and in part by the National Science Foundation (BME 1605130, CBET 1703402, CBET 2023668). The contents of this manuscript do not necessarily reflect the views of the funding agencies.en_US
CitationHuang, Haofu, and Kristi Kiick. “Peptide-Based Assembled Nanostructures That Can Direct Cellular Responses.” Biomedical Materials 17, no. 6 (2022): 062002. https://doi.org/10.1088/1748-605X/ac92b5.en_US
ISSN1748-605X
URLhttps://udspace.udel.edu/handle/19716/31435
Languageen_USen_US
PublisherBiomedical Materialsen_US
Keywordspeptidesen_US
Keywordsself-assemblyen_US
Keywordsnanoparticlesen_US
Keywordsbioactive materialsen_US
Keywordsdrug deliveryen_US
Keywordsstimuli-responsivenessen_US
Keywordscellular uptakeen_US
TitlePeptide-based assembled nanostructures that can direct cellular responsesen_US
TypeArticleen_US
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