Peptide-based assembled nanostructures that can direct cellular responses

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Biomedical Materials
Natural originated materials have been well-studied over the past several decades owing to their higher biocompatibility compared to the traditional polymers. Peptides, consisting of amino acids, are among the most popular programmable building blocks, which is becoming a growing interest in nanobiotechnology. Structures assembled using those biomimetic peptides allow the exploration of chemical sequences beyond those been routinely used in biology. In this review, we discussed the most recent experimental discoveries on the peptide-based assembled nanostructures and their potential application at the cellular level such as drug delivery. In particular, we explored the fundamental principles of peptide self-assembly and the most recent development in improving their interactions with biological systems. We believe that as the fundamental knowledge of the peptide assemblies evolves, the more sophisticated and versatile nanostructures can be built, with promising biomedical applications.
This is an author-created, un-copyedited version of an article accepted for publication/publishedin Biomedical Materials. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at This article will be embargoed until 09/29/2023.
peptides, self-assembly, nanoparticles, bioactive materials, drug delivery, stimuli-responsiveness, cellular uptake
Huang, Haofu, and Kristi Kiick. “Peptide-Based Assembled Nanostructures That Can Direct Cellular Responses.” Biomedical Materials 17, no. 6 (2022): 062002.