Outer Membrane Vesicles (OMVs) Enabled Bio-applications: A critical review
Date
2021-10-26
Journal Title
Journal ISSN
Volume Title
Publisher
Biotechnology and Bioengineering
Abstract
Outer membrane vesicles (OMVs) are nanoscale spherical vesicles released from Gram-negative bacteria. The lipid bilayer membrane structure of OMVs consists of similar components as bacterial membrane and thus has attracted more and more attention in exploiting OMVs' bio-applications. Although the endotoxic lipopolysaccharide on natural OMVs may impose potential limits on their clinical applications, genetic modification can reduce their endotoxicity and decorate OMVs with multiple functional proteins. These genetically engineered OMVs have been employed in various fields including vaccination, drug delivery, cancer therapy, bioimaging, biosensing, and enzyme carrier. This review will first briefly introduce the background of OMVs followed by recent advances in functionalization and various applications of engineered OMVs with an emphasis on the working principles and their performance, and then discuss about the future trends of OMVs in biomedical applications.
Description
This article was originally published in Biotechnology and Bioengineering. The version of record is available at: https://doi.org/10.1002/bit.27965
Keywords
bioimaging, drug delivery, enzyme carrier, immunoassay, outer membrane vesicles, vaccine
Citation
Huang, Y., Nieh, M.-P., Chen, W., & Lei, Y. (2022). Outer Membrane Vesicles (OMVs) Enabled Bio-applications: A critical review. Biotechnology and Bioengineering, 119, 34– 47. https://doi.org/10.1002/bit.27965