Outer Membrane Vesicles (OMVs) Enabled Bio-applications: A critical review
| Author(s) | Huang, Yikun | |
| Author(s) | Nieh, Mu-Ping | |
| Author(s) | Chen, Wilfred | |
| Author(s) | Lei, Yu | |
| Date Accessioned | 2022-01-31T19:45:30Z | |
| Date Available | 2022-01-31T19:45:30Z | |
| Publication Date | 2021-10-26 | |
| Description | This article was originally published in Biotechnology and Bioengineering. The version of record is available at: https://doi.org/10.1002/bit.27965 | en_US |
| Abstract | Outer membrane vesicles (OMVs) are nanoscale spherical vesicles released from Gram-negative bacteria. The lipid bilayer membrane structure of OMVs consists of similar components as bacterial membrane and thus has attracted more and more attention in exploiting OMVs' bio-applications. Although the endotoxic lipopolysaccharide on natural OMVs may impose potential limits on their clinical applications, genetic modification can reduce their endotoxicity and decorate OMVs with multiple functional proteins. These genetically engineered OMVs have been employed in various fields including vaccination, drug delivery, cancer therapy, bioimaging, biosensing, and enzyme carrier. This review will first briefly introduce the background of OMVs followed by recent advances in functionalization and various applications of engineered OMVs with an emphasis on the working principles and their performance, and then discuss about the future trends of OMVs in biomedical applications. | en_US |
| Sponsor | National Science Foundation, Grant/Award Number: CBET1604925 and CBET1604826; GE Fellowship; NSF, Grant/Award Numbers: CBET1604925, CBET1604826 | en_US |
| Citation | Huang, Y., Nieh, M.-P., Chen, W., & Lei, Y. (2022). Outer Membrane Vesicles (OMVs) Enabled Bio-applications: A critical review. Biotechnology and Bioengineering, 119, 34– 47. https://doi.org/10.1002/bit.27965 | en_US |
| ISSN | 1097-0290 | |
| URL | https://udspace.udel.edu/handle/19716/30222 | |
| Language | en_US | en_US |
| Publisher | Biotechnology and Bioengineering | en_US |
| Keywords | bioimaging | en_US |
| Keywords | drug delivery | en_US |
| Keywords | enzyme carrier | en_US |
| Keywords | immunoassay | en_US |
| Keywords | outer membrane vesicles | en_US |
| Keywords | vaccine | en_US |
| Title | Outer Membrane Vesicles (OMVs) Enabled Bio-applications: A critical review | en_US |
| Type | Article | en_US |
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