Open Access Publications

Permanent URI for this collection

Open access publications by faculty, postdocs, and graduate students in the Department of Psychological and Brain Sciences

Browse

Recent Submissions

Now showing 1 - 20 of 79
  • Item
    Negative Urgency and Lack of Perseverance Predict Suicidal Ideation and Attempts Among Young Adolescents
    (Journal of Clinical Child & Adolescent Psychology, 2024-11-21) Scheve, Ben; Xianga, Zhuoran; Lam, Brendan; Sadeh, Naomi; Baskin-Sommers, Arielle
    Objective Impulsivity has been recognized as an important factor in suicidal thoughts and behaviors (STBs). However, previous research linking impulsivity to STBs has largely relied on cross-sectional designs, considered only a subset of impulsivity measures, and typically focused on middle-to-older adolescents. Here, we explored multiple measures of impulsivity and assessed their predictive relation to suicidal ideation and suicide attempts. Method In a sample of 10,286 adolescents (ages 9–12; 47.4% female, 76.4% White, 19.4% Black, 6.4% Asian, 3.5% American Indian/Alaskan Native, 0.6% Native Hawaiian/Pacific Islander, 6.4% Other, 19.4% Hispanic, 12.1% Mixed/Multiple Race) from the Adolescent Brain Cognitive Development℠ Study (ABCD Study®), we assessed impulsivity when youth were 9–10 years old, and suicidal ideation and attempts when youth were 11–12 years old. We measured impulsivity in three ways: a trait-like measure (UPPS-P Impulsive Behavior Scale), a behavioral measure (delay discounting task), and a neural measure (Cortical Delay Discounting [C-DD]). Suicidal ideation and attempts were assessed using the Kiddie Schedule for Affective Disorder and Schizophrenia (KSADS) suicide module. Results Negative urgency and lack of perseverance (at ages 9–10) significantly predicted a higher likelihood of suicidal ideation (Negative Urgency: Odds Ratio [OR] = 1.254, p < .001; Lack of Perseverance: OR = 1.152, p = .035) and suicide attempts (Negative Urgency: OR = 1.328, p = .009; Lack of Perseverance: OR = 1.270, p = .009) when youth were 11–12 years old. Conclusions Negative urgency and lack of perseverance are robust predictors of future suicidal ideation and suicide attempts in young adolescents. These findings highlight the importance of assessing for and targeting these dimensions of impulsivity in clinical settings.
  • Item
    Deciphering the Neural Effects of Emotional, Motivational, and Cognitive Challenges on Inhibitory Control Processes
    (Human Brain Mapping, 2025-01-24) Bounoua, Nadia; Stumps, Anna; Church, Leah; Spielberg, Jeffrey M.; Sadeh, Naomi
    Converging lines of research indicate that inhibitory control is likely to be compromised in contexts that place competing demands on emotional, motivational, and cognitive systems, potentially leading to damaging impulsive behavior. The objective of this study was to identify the neural impact of three challenging contexts that typically compromise self-regulation and weaken impulse control. Participants included 66 healthy adults (M/SDage = 29.82/10.21 years old, 63.6% female) who were free of psychiatric disorders and psychotropic medication use. Participants completed a set of novel Go/NoGo (GNG) paradigms in the scanner, which manipulated contextual factors to induce (i) aversive emotions, (ii) appetitive drive, or (iii) concurrent working memory load. Voxelwise analysis of neural activation during each of these tasks was compared to that of a neutral GNG task. Findings revealed differential inhibition-related activation in the aversive emotions and appetitive drive GNG tasks relative to the neutral task in frontal, parietal and temporal cortices, suggesting emotional and motivational contexts may suppress activation of these cortical regions during inhibitory control. In contrast, the GNG task with a concurrent working memory load showed widespread increased activation across the cortex compared to the neutral task, indicative of enhanced recruitment of executive control regions. Results suggest the neural circuitry recruited for inhibitory control varies depending on the concomitant emotional, motivational, and cognitive demands of a given context. This battery of GNG tasks can be used by researchers interested in studying unique patterns of neural activation associated with inhibitory control across three clinically relevant contexts that challenge self-regulation and confer risk for impulsive behavior. Summary - Examining the impact of context on the neural mechanisms supporting inhibitory control is critical for furthering the field's understanding of self-regulation. - This study assessed the utility of three new fMRI Go/NoGo tasks for examining how emotional, motivational, and cognitive contexts influence the neural circuits involved in inhibitory control. - Results revealed differential recruitment of inhibitory control-related brain regions depending on contextual demands, underscoring the utility of examining inhibitory control across challenging contexts using these novel Go/NoGo fMRI tasks.
  • Item
    Gene Expression After Exercise Is Disrupted by Early-Life Stress
    (Developmental Psychobiology, 2025-01-08) Campbell, Taylor S.; Donoghue, Katelyn; Roth, Tania L.
    Exercise can be leveraged as an important tool to improve neural and psychological health, either on its own or to bolster the efficacy of evidence-based treatment modalities. Research in both humans and animal models shows that positive experiences, such as exercise, promote neuroprotection while, in contrast, aversive experiences, particularly those in early development, are often neurologically and psychologically disruptive. In the current study, we employed a preclinical model to investigate the therapeutic benefits of exercise on gene expression in the brains of adult rats. Long Evans rats were exposed to maltreatment stress or nurturing care during infancy, with some rats later given voluntary running wheels as an aerobic exercise intervention from Postnatal Days 70 to 90. Our results showed that irisin gene expression, which promotes neuroprotection, was differentially affected by exercise and early exposure to stress. We add to a rapidly growing area of research on the neuroprotective benefits of exercise and shed light on important molecular mechanisms that may affect the efficacy of exercise in different individuals.
  • Item
    Prey Cue Preferences Among Northern Cottonmouths (Agkistrodon piscivorus) Acclimated to Different Year-Long Diets: Genetics or Experienced-Based Plasticity?
    (Integrative Organismal Biology, 2024-11-08) Lutterschmidt, William I.; Perelman, Zander E.; Roth, Eric D.; Weidler, J.M.
    Chemoreception and recognition of specific prey are important sensory modalities for optimizing foraging success in snakes. Field observations suggest that cottonmouths are generalists, despite the specific epithet of the species (piscivorus) suggesting a fish prey preference. Because chemo-recognition of specific prey may reveal interesting evolutionary context for foraging strategy and if prey preference is either genetically or environmentally controlled, we investigated the prey cue preference of three experimental groups of Agkistrodon piscivorus (Northern Cottonmouths) with different diet histories. Two groups of captive snakes were acclimated to year-long diets of either fish (n = 11) or mice (n = 9) and a third group of recently wild-caught individuals served as a field diet group (n = 16). We investigated possible differences among diet history (fish, mouse, and field) and prey cue preference (control, fish, and mouse) and present results showing a significant difference among diet history with field snakes having significantly lower tongue-flick response. We also found a significant difference among prey cues, snakes within all diet histories showed a lower tongue-flick response to only the control scent cue. Both captive and field snakes showed no prey cue preference for either fish or mice. Because captive snakes did not show increased prey cue preference to their respective diet history, prey preference may be under genetic influence and not experience-based. Additionally, the lack of prey preference for fish or mice in the recently captured snakes in the field-diet group provides supporting evidence that A. piscivorus are generalists and opportunistic predators.
  • Item
    Fear of cancer recurrence and change in hair cortisol concentrations in partners of breast cancer survivors
    (Journal of Cancer Survivorship, 2024-07-02) Fenech, Alyssa L.; Soriano, Emily C.; Asok, Arun; Siegel, Scott D.; Morreale, Michael; Brownlee, Hannah A.; Laurenceau, Jean-Philippe
    Purpose Partners of breast cancer (BC) survivors report high rates of psychological distress including fear of cancer recurrence (FCR). Research suggests that partners may have poorer physical health outcomes than the general population, but little research has examined the physiological biomarkers by which distress may impact partner health outcomes. The current study examined the associations between FCR and changes in hair cortisol among BC partners. Methods Male partners (N = 73) of early-stage BC survivors provided hair samples during two visits, one after completion of survivors’ adjuvant treatment (T1) and again 6 months later (T2). Two subscales from the Fear of Cancer Recurrence Inventory and one subscale from the Concerns about Recurrence Scale comprised a latent FCR factor at T1. A latent change score model was used to examine change in cortisol as a function of FCR. Results Partners were on average 59.65 years of age (SD = 10.53) and non-Hispanic White (83%). Latent FCR at T1 was positively associated (b = 0.08, SE = 0.03, p = .004, standardized β = .45) with change in latent hair cortisol from T1 to T2. Conclusions Results indicated that greater FCR was associated with increases in hair cortisol in the months following adjuvant treatment. This is one of the first studies to examine the physiological correlates of FCR that may impact health outcomes in BC partners. Implications for Cancer Survivors. Findings highlight the need for further research into the relationship between FCR and its physiological consequences. Interventions to address partner FCR are needed and may aid in improving downstream physical health outcomes.
  • Item
    Using deep learning to classify developmental differences in reaching and placing movements in children with and without autism spectrum disorder
    (Scientific Reports, 2024-12-05) Su, Wan-Chun; Mutersbaugh, John; Huang, Wei-Lun; Bhat, Anjana; Gandjbakhche, Amir
    Autism Spectrum Disorder (ASD) is among the most prevalent neurodevelopmental disorders, yet the current diagnostic procedures rely on behavioral analyses and interviews, without objective screening methods to support the diagnostic process. This study seeks to address this gap by integrating upper limb kinematics and deep learning methods to identify potential biomarkers that could be validated in younger age groups in the future to enhance the identification of ASD. Forty-one school-age children, with and without an ASD diagnosis (mean age ± SE: TD group: 10.3 ± 0.8, 8 males and 7 females; ASD group: 10.3 ± 0.5, 21 males and 5 females), participated in the study. A single Inertial Measurement Unit (IMU) was affixed to the child’s wrist as they engaged in a continuous reaching and placing task. Deep learning techniques were employed to classify children with and without ASD. Our findings suggest differential movement kinematics in school-age children compared to healthy adults. Compared to TD children, children with ASD exhibited poor feedforward/feedback control of arm movements as seen by greater number of movement units, more movement overshooting, and prolonged time to peak velocity/acceleration. Unique movement strategies such as greater velocity and acceleration were also seen in the ASD group. More importantly, using Multilayer Perceptron (MLP) model, we demonstrated an accuracy of ~ 78.1% in classifying children with and without ASD. These findings underscore the potential use of studying upper limb movement kinematics during goal-directed arm movements and deep learning methods as valuable tools for classifying and, consequently, aiding in the diagnosis and early identification of ASD upon further validation of their specificity among younger children.
  • Item
    Harnessing slow event-related fMRI to investigate trial-level brain-behavior relationships during object identification
    (Frontiers in Human Neuroscience, 2024-11-11) Gotts, Stephen J.; Gilmore, Adrian W.; Martin, Alex
    Understanding brain-behavior relationships is the core goal of cognitive neuroscience. However, these relationships—especially those related to complex cognitive and psychopathological behaviors—have recently been shown to suffer from very small effect sizes (0.1 or less), requiring potentially thousands of participants to yield robust findings. Here, we focus on a much more optimistic case utilizing task-based fMRI and a multi-echo acquisition with trial-level brain-behavior associations measured within participant. In a visual object identification task for which the behavioral measure is response time (RT), we show that while trial-level associations between BOLD and RT can similarly suffer from weak effect sizes, converting these associations to their corresponding group-level effects can yield robust peak effect sizes (Cohen’s d = 1.0 or larger). Multi-echo denoising (Multi-Echo ICA or ME-ICA) yields larger effects than optimally combined multi-echo with no denoising, which is in turn an improvement over standard single-echo acquisition. While estimating these brain-behavior relationships benefits from the inclusion of a large number of trials per participant, even a modest number of trials (20–30 or more) yields robust group-level effect sizes, with replicable effects obtainable with relatively standard sample sizes (N = 20–30 participants per sample).
  • Item
    The Importance of Including Maternal Immune Activation in Animal Models of Hypoxic–Ischemic Encephalopathy
    (Biomedicines, 2024-11-08) Collins, Bailey; Lemanski, Elise A.; Wright-Jin, Elizabeth
    Hypoxic–ischemic encephalopathy (HIE) is a perinatal brain injury that is the leading cause of cerebral palsy, developmental delay, and poor cognitive outcomes in children born at term, occurring in about 1.5 out of 1000 births. The only proven therapy for HIE is therapeutic hypothermia. However, despite this treatment, many children ultimately suffer disability, brain injury, and even death. Barriers to implementation including late diagnosis and lack of resources also lead to poorer outcomes. This demonstrates a critical need for additional treatments for HIE, and to facilitate this, we need translational models that accurately reflect risk factors and interactions present in HIE. Maternal or amniotic infection is a significant risk factor and possible cause of HIE in humans. Maternal immune activation (MIA) is a well-established model of maternal infection and inflammation that has significant developmental consequences largely characterized within the context of neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. MIA can also lead to long-lasting changes within the neuroimmune system, which lead to compounding negative outcomes following a second insult. This supports the importance of understanding the interaction of maternal inflammation and hypoxic–ischemic outcomes. Animal models have been invaluable to understanding the pathophysiology of this injury and to the development of therapeutic hypothermia. However, each model system has its own limitations. Large animal models such as pigs may more accurately represent the brain and organ development and complexity in humans, while rodent models are more cost-effective and offer more possible molecular techniques. Recent studies have utilized MIA or direct inflammation prior to HIE insult. Investigators should thoughtfully consider the risk factors they wish to include in their HIE animal models. In the incorporation of MIA, investigators should consider the type, timing, and dose of the inflammatory stimulus, as well as the timing, severity, and type of hypoxic insult. Using a variety of animal models that incorporate the maternal–placental–fetal system of inflammation will most likely lead to a more robust understanding of the mechanisms of this injury that can guide future clinical decisions and therapies.
  • Item
    Viewed touch influences tactile detection by altering decision criterion
    (Attention, Perception, & Psychophysics, 2024-11-05) Nair, Anupama; Medina, Jared
    Our tactile perception is shaped not only by somatosensory input but also by visual information. Prior research on the effect of viewing touch on tactile processing has found higher tactile detection rates when paired with viewed touch versus a control visual stimulus. Therefore, some have proposed a vicarious tactile system that activates somatosensory areas when viewing touch, resulting in enhanced tactile perception. However, we propose an alternative explanation: Viewing touch makes the observer more liberal in their decision to report a tactile stimulus relative to not viewing touch, also resulting in higher tactile detection rates. To disambiguate between the two explanations, we examined the effect of viewed touch on tactile sensitivity and decision criterion using signal detection theory. In three experiments, participants engaged in a tactile detection task while viewing a hand being touched or approached by a finger, a red dot, or no stimulus. We found that viewing touch led to a consistent, liberal criterion shift but inconsistent enhancement in tactile sensitivity relative to not viewing touch. Moreover, observing a finger approach the hand was sufficient to bias the criterion. These findings suggest that viewing touch influences tactile performance by altering tactile decision mechanisms rather than the tactile perceptual signal.
  • Item
    Self-assembled thin films as alternative surface textures in assistive aids with users who are blind
    (Journal of Materials Chemistry B, 2024-09-05) Swain, Zachary; Derkaloustian, Maryanne; Hepler, Kayla A.; Nolin, Abigail; Damani, Vidhika S.; Bhattacharyya, Pushpita; Shrestha, Tulaja; Medina, Jared; Kayser, Laure V.; Dhong, Charles B.
    Current tactile graphics primarily render tactile information for blind users through physical features, such as raised bumps or lines. However, the variety of distinctive physical features that can be created is effectively saturated, and alternatives to these physical features are not currently available for static tactile aids. Here, we explored the use of chemical modification through self-assembled thin films to generate distinctive textures in tactile aids. We used two silane precursors, n-butylaminopropyltrimethoxysilane and n-pentyltrichlorosilane, to coat playing card surfaces and investigated their efficacy as a tactile coating. We verified the surface coating process and examined their durability to repeated use by traditional materials characterization and custom mesoscale friction testing. Finally, we asked participants who were both congenitally blind and braille-literate to sort the cards based on touch. We found that participants were able to identify the correct coated card with 82% accuracy, which was significantly above chance, and two participants achieved 100% accuracy. This success with study participants demonstrates that surface coatings and surface modifications might augment or complement physical textures in next-generation tactile aids.
  • Item
    Mice employ a bait-and-switch escape mechanism to de-escalate social conflict
    (PLoS Biology, 2024-10-15) Clein, Rachel S.; Warren, Megan R.; Neunuebel, Joshua P.
    Intraspecies aggression has profound ecological and evolutionary consequences, as recipients can suffer injuries, decreases in fitness, and become outcasts from social groups. Although animals implement diverse strategies to avoid hostile confrontations, the extent to which social influences affect escape tactics is unclear. Here, we used computational and machine-learning approaches to analyze complex behavioral interactions as mixed-sex groups of mice, Mus musculus, freely interacted. Mice displayed a rich repertoire of behaviors marked by changes in behavioral state, aggressive encounters, and mixed-sex interactions. A distinctive behavioral sequence consistently occurred after aggressive encounters, where males in submissive states quickly approached and transiently interacted with females immediately before the aggressor engaged with the same female. The behavioral sequences were also associated with substantially fewer physical altercations. Furthermore, the male’s behavioral state could be predicted by distinct features of the behavioral sequence, such as kinematics and the latency to and duration of male–female interactions. More broadly, our work revealed an ethologically relevant escape strategy influenced by the presence of females that may serve as a mechanism for de-escalating social conflict and preventing consequential reductions in fitness.
  • Item
    Early Childhood Sleep Difficulties and Middle Childhood Internalizing and Externalizing Psychopathology Among Children with Histories of Early Adversity
    (International Journal on Child Maltreatment, 2024-08-12) Lee, Amy Hyoeun; Bernard, Kristin; Dozier, Mary
    Children who have experienced adversity, including abuse and neglect, are at elevated risk for both sleep problems and psychopathology. Sleep disturbance may be one pathway by which early adversity confers risk for psychopathology. Previous studies with such children have found associations between sleep difficulties and internalizing and externalizing problems in early childhood, and between sleep and externalizing problems in middle childhood. Here, we sought to examine the links between early childhood sleep difficulties and middle childhood internalizing and externalizing psychopathology in children with histories of early adversity followed longitudinally. Participants were 153 children (44% female) enrolled in a randomized controlled trial of an early childhood parenting intervention following involvement with child protective services. Caregivers reported on children’s sleep difficulties at ages 2, 3, and 4 and children’s internalizing and externalizing problems at ages 8, 9, and 10. Using a structural equation modeling approach, we found that mean levels of early childhood sleep difficulties were significantly and positively associated with internalizing, β = .449, p = .010, 95% CI [.106, .792], but not with externalizing, β = .229, p = .137, 95% CI [-.072, .529], problems in middle childhood, controlling for sex, age 4 psychopathology, and caregiver depression. Findings extend prior work demonstrating associations between sleep problems and psychopathology among children with histories of early adversity. More research is needed to elucidate the potential role of sleep difficulties in the development of internalizing problems in this population.
  • Item
    Longitudinal Change in Appearance-Related Social Media Consciousness and Depressive Symptoms: A Within-Person Analysis during Early-to-Middle Adolescence
    (Journal of Youth and Adolescence, 2024-05-24) Maheux, Anne J.; Laurenceau, Jean-Philippe; Roberts, Savannah R.; Nesi, Jacqueline; Widman, Laura; Choukas-Bradley, Sophia
    Online appearance preoccupation may put adolescents at risk of developing mental health challenges, perhaps especially during early-to-middle adolescence. A random intercept cross-lagged panel model assessed within-person associations between appearance-related social media consciousness and depressive symptoms over three time-points with three months between waves. The sample (n = 1594) included U.S. adolescents aged 11–15 (Mage = 13; 47% girls, 46% boys, 7% another gender; 37% Latine, 33% White, 18% Black, 7% Asian). Within-person increases in appearance-related social media consciousness were associated with subsequent increases in depressive symptoms, but not vice versa. There was no evidence of gender differences and results were robust to controlling for both time on social media and offline self-objectification. Thus, online appearance concerns precede mental health challenges during early and middle adolescence.
  • Item
    Intergenerational transmission of maternal prenatal anxiety to infant fearfulness: the mediating role of mother-infant bonding
    (Archives of Women's Mental Health, 2024-06-11) Rousseau, Sofie; Katz, Danielle; Schussheim, Avital; Frenkel, Tahl I.
    Purpose This study is the first to directly investigate the mechanistic role of maternal bonding toward her infant in the early intergenerational pathway of risk from maternal anxiety to infant fearfulness. Methods Mothers (N = 216; Mage=32.78) reported on their anxiety and bonding at four time-points between pregnancy and ten-months postpartum. At four and ten-months postpartum, infant temperamental precursors of anxiety were assessed through maternal report and observation. Results Cross-lagged longitudinal path modeling indicated a significant link between prenatal maternal anxiety and infant temperamental fearful withdrawal at 10-months postpartum (R2 = 0.117), which was fully explained by decreased maternal bonding at one-month postpartum and increased infant temperamental negative reactivity at 4-months postpartum. Conclusion Results support the need to foster maternal bonding in preventive perinatal care, particularly in the context of maternal anxiety.
  • Item
    The psychological costs of behavioral immunity following COVID-19 diagnosis
    (Scientific Reports, 2024-04-30) Spangler, Derek P.; Li, Evaline Y.; Revi, Gabriela S.; Kubota, Jennifer T.; Cloutier, Jasmin; Lauharatanahirun, Nina
    Prior COVID-19 infection may elevate activity of the behavioral immune system—the psychological mechanisms that foster avoidance of infection cues—to protect the individual from contracting the infection in the future. Such “adaptive behavioral immunity” may come with psychological costs, such as exacerbating the global pandemic’s disruption of social and emotional processes (i.e., pandemic disruption). To investigate that idea, we tested a mediational pathway linking prior COVID infection and pandemic disruption through behavioral immunity markers, assessed with subjective emotional ratings. This was tested in a sample of 734 Mechanical Turk workers who completed study procedures online during the global pandemic (September 2021–January 2022). Behavioral immunity markers were estimated with an affective image rating paradigm. Here, participants reported experienced disgust/fear and appraisals of sickness/harm risk to images varying in emotional content. Participants self-reported on their previous COVID-19 diagnosis history and level of pandemic disruption. The findings support the proposed mediational pathway and suggest that a prior COVID-19 infection is associated with broadly elevated threat emotionality, even to neutral stimuli that do not typically elicit threat emotions. This elevated threat emotionality was in turn related to disrupted socioemotional functioning within the pandemic context. These findings inform the psychological mechanisms that might predispose COVID survivors to mental health difficulties.
  • Item
    Seeing without a Scene: Neurological Observations on the Origin and Function of the Dorsal Visual Stream
    (Journal of Intelligence, 2024-05-11) Rafal, Robert D.
    In all vertebrates, visual signals from each visual field project to the opposite midbrain tectum (called the superior colliculus in mammals). The tectum/colliculus computes visual salience to select targets for context-contingent visually guided behavior: a frog will orient toward a small, moving stimulus (insect prey) but away from a large, looming stimulus (a predator). In mammals, visual signals competing for behavioral salience are also transmitted to the visual cortex, where they are integrated with collicular signals and then projected via the dorsal visual stream to the parietal and frontal cortices. To control visually guided behavior, visual signals must be encoded in body-centered (egocentric) coordinates, and so visual signals must be integrated with information encoding eye position in the orbit—where the individual is looking. Eye position information is derived from copies of eye movement signals transmitted from the colliculus to the frontal and parietal cortices. In the intraparietal cortex of the dorsal stream, eye movement signals from the colliculus are used to predict the sensory consequences of action. These eye position signals are integrated with retinotopic visual signals to generate scaffolding for a visual scene that contains goal-relevant objects that are seen to have spatial relationships with each other and with the observer. Patients with degeneration of the superior colliculus, although they can see, behave as though they are blind. Bilateral damage to the intraparietal cortex of the dorsal stream causes the visual scene to disappear, leaving awareness of only one object that is lost in space. This tutorial considers what we have learned from patients with damage to the colliculus, or to the intraparietal cortex, about how the phylogenetically older midbrain and the newer mammalian dorsal cortical visual stream jointly coordinate the experience of a spatially and temporally coherent visual scene.
  • Item
    Trait dimensions of anticipatory and consummatory reward relate differently to self-injurious thoughts and behaviors in a community adult sample
    (Journal of Affective Disorders Reports, 2024-04-26) Huerta, Wendy; Bounoua, Nadia; Sadeh, Naomi
    Background Self-injurious thoughts and behaviors (SITBs) are a major problem worldwide and continue to be a serious public health concern. Research investigating risk factors for suicide has shown that reward processes, such as the inability to feel pleasure, may confer risk for SITBs. However, less work has examined how different dimensions of trait reward relate to SITBs. Accordingly, the present study investigated the unique and interactive effects of trait anticipatory and consummatory reward for explaining SITBs. Methods 260 community adults ages 18–55 (M/SD = 32.79/10.54, females = 49.6 %, males = 50.4 %) completed an interview, neuropsychological tests, and questionnaires. We used hierarchical multivariate multiple regression analysis to assess cross-sectional associations between trait anticipatory and consummatory reward and different types of SITBs [self-injurious thoughts, nonsuicidal self-injury (NSSI), and suicide attempts] from the Risky, Impulsive, and Self-destructive Behavior Questionnaire. Results The unique variance associated with anticipatory and consummatory reward were differentially related to self-injurious thoughts but unrelated to self-injurious behaviors (NSSI/suicide attempts). The interaction of anticipatory and consummatory reward was associated with self-injurious behavior, such that the inability to experience both anticipatory and consummatory reward was associated with higher frequency of NSSI. Limitations Limitations of the study include its cross-sectional nature and reliance on self-reported measures. Conclusions Low anticipatory reward and high consummatory reward may confer risk for self-injurious thoughts. Low levels of both trait anticipatory and consummatory reward may confer risk for NSSI. Findings suggest reward sensitivity may be an understudied risk factor for a range of SITBs.
  • Item
    NF-κB as an Inducible Regulator of Inflammation in the Central Nervous System
    (Cells, 2024-03-11) Anilkumar, Sudha; Wright-Jin, Elizabeth
    The NF-κB (nuclear factor K-light-chain-enhancer of activated B cells) transcription factor family is critical for modulating the immune proinflammatory response throughout the body. During the resting state, inactive NF-κB is sequestered by IκB in the cytoplasm. The proteasomal degradation of IκB activates NF-κB, mediating its translocation into the nucleus to act as a nuclear transcription factor in the upregulation of proinflammatory genes. Stimuli that initiate NF-κB activation are diverse but are canonically attributed to proinflammatory cytokines and chemokines. Downstream effects of NF-κB are cell type-specific and, in the majority of cases, result in the activation of pro-inflammatory cascades. Acting as the primary immune responders of the central nervous system, microglia exhibit upregulation of NF-κB upon activation in response to pathological conditions. Under such circumstances, microglial crosstalk with other cell types in the central nervous system can induce cell death, further exacerbating the disease pathology. In this review, we will emphasize the role of NF-κB in triggering neuroinflammation mediated by microglia.
  • Item
    Network-based analysis predicts interacting genetic modifiers from a meta-mapping study of spike–wave discharge in mice
    (Genes, Brain and Behavior, 2024-03-05) Lara, Montana Kay; Brabec, Jeffrey L.; Hernan, Amanda E.; Scott, Rod C.; Tyler, Anna L.; Mahoney, J. Matthew
    Absence seizures are characterized by brief lapses in awareness accompanied by a hallmark spike-and-wave discharge (SWD) electroencephalographic pattern and are common to genetic generalized epilepsies (GGEs). While numerous genes have been associated with increased risk, including some Mendelian forms with a single causal allele, most cases of GGE are idiopathic and there are many unknown genetic modifiers of GGE influencing risk and severity. In a previous meta-mapping study, crosses between transgenic C57BL/6 and C3HeB/FeJ strains, each carrying one of three SWD-causing mutations (Gabrg2tm1Spet(R43Q), Scn8a8j or Gria4spkw1), demonstrated an antagonistic epistatic interaction between loci on mouse chromosomes 2 and 7 influencing SWD. These results implicate universal modifiers in the B6 background that mitigate SWD severity through a common pathway, independent of the causal mutation. In this study, we prioritized candidate modifiers in these interacting loci. Our approach integrated human genome-wide association results with gene interaction networks and mouse brain gene expression to prioritize candidate genes and pathways driving variation in SWD outcomes. We considered candidate genes that are functionally associated with human GGE risk genes and genes with evidence for coding or non-coding allele effects between the B6 and C3H backgrounds. Our analyses output a summary ranking of gene pairs, one gene from each locus, as candidates for explaining the epistatic interaction. Our top-ranking gene pairs implicate microtubule function, cytoskeletal stability and cell cycle regulation as novel hypotheses about the source of SWD variation across strain backgrounds, which could clarify underlying mechanisms driving differences in GGE severity in humans.
  • Item
    Using randomized controlled trials to ask questions regarding developmental psychopathology: A tribute to Dante Cicchetti
    (Development and Psychopathology, 2024-02-28) Miller, Kristen N.; Bourne, Stacia V.; Dahl, Claire M.; Costello, Christopher; Attinelly, Jillian; Jennings, Kathryn; Dozier, Mary
    Dante Cicchetti, the architect of developmental psychopathology, has influenced so many of us in profound ways. One of his many contributions was in demonstrating the power of randomized controlled trials (RCTs) to study the effects of Child–Parent Psychotherapy (CPP). These RCTs have shed light on causal mechanisms in development. Following Cicchetti and colleagues’ work, we designed a brief home visiting program, Attachment and Biobehavioral Catch-up (ABC), to help parents respond in sensitive, nurturing ways, so as to enhance children’s attachment and self-regulatory capabilities. In the current study, we assessed adolescents’ reports of the closeness of their relationships with their mothers 12 years after their mothers completed the intervention. A total of 142 adolescents participated (47 randomized to ABC, 45 randomized to a control intervention, and 50 from a low-risk comparison group). Adolescents whose mothers had been randomized to ABC reported closer relationships with their mothers than adolescents randomized to the control condition, with significant differences seen on approval, support, companionship, and emotional support subscales. Consistent with Cicchetti et al.’s work, these results provide powerful evidence of the long-term effects of an early parenting intervention.
Please look at individual material in order to see what the copyright and licensing terms are. Some material may be available for reuse under a Creative Commons license; other material may be the copyright of the individual author(s) or the publisher of the journal.