Corticotropin releasing factor type-1 receptor antagonism in the dorsolateral bed nucleus of the stria terminalis disrupts contextually conditioned fear, but not unconditioned fear to a predator odor
| Author(s) | Asok, Arun | |
| Author(s) | Schulkin, Jay | |
| Author(s) | Rosen, Jeffrey B. | |
| Ordered Author | Arun Asok, Jay Schulkin & Jeffrey B. Rosen | |
| UD Author | Asok, Arun | en_US |
| UD Author | Rosen, Jeffrey B. | en_US |
| Date Accessioned | 2016-10-12T18:38:58Z | |
| Date Available | 2016-10-12T18:38:58Z | |
| Copyright Date | Copyright © 2016 Elsevier Ltd | en_US |
| Publication Date | 2016-04-27 | |
| Description | Author's final draft after peer review | en_US |
| Abstract | The bed nucleus of the stria terminalis (BNST) plays a critical role in fear and anxiety. The BNST is important for contextual fear learning, but the mechanisms regulating this function remain unclear. One candidate mechanism is corticotropin-releasing-factor (CRF) acting at CRF type 1 receptors (CRFr1s). Yet, there has been little progress in elucidating if CRFr1s in the BNST are involved in different types of fear (conditioned and/or unconditioned). Therefore, the present study investigated the effect of antalarmin, a potent CRFr1 receptor antagonist, injected intracerebroventricularly (ICV) and into the dorsolateral BNST (LBNST) during single trial contextual fear conditioning or exposure to the predator odor 2,5-dihydro-2,4,5- trimethylthiazoline (TMT). Neither ICV nor LBNST antalarmin disrupted unconditioned freezing to TMT. In contrast, ICV and LBNST antalarmin disrupted the retention of contextual fear when tested 24 hours later. Neither ICV nor LBNST antalarmin affected baseline or post-shock freezing – indicating antalarmin does not interfere with the early phases of contextual fear acquisition. Antalarmin did not (1) permanently affect the ability to learn and express contextual fear, (2) change responsivity to footshocks, or (3) affect the ability to freeze. Our findings highlight an important role for CRFr1s within the LBNST during contextually conditioned fear, but not unconditioned predator odor fear. | en_US |
| Department | University of Delaware. Department of Psychological & Brain Sciences. | en_US |
| Citation | Asok, Arun, Schulkin, Jay, Rosen, Jeffrey B., Corticotropin releasing factor type-1 receptor antagonism in the dorsolateral bed nucleus of the stria terminalis disrupts contextually conditioned fear, but not unconditioned fear to a predator odor.Psychoneuroendocrinology http://dx.doi.org/10.1016/j.psyneuen.2016.04.021 | en_US |
| DOI | http://dx.doi.org/10.1016/j.psyneuen.2016.04.021 | en_US |
| ISSN | 0306-4530 | en_US |
| URL | http://udspace.udel.edu/handle/19716/19803 | |
| Language | en_US | en_US |
| Publisher | Elsevier | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | Psychoneuroendocrinology | en_US |
| dc.source.uri | http://www.journals.elsevier.com/psychoneuroendocrinology | en_US |
| Title | Corticotropin releasing factor type-1 receptor antagonism in the dorsolateral bed nucleus of the stria terminalis disrupts contextually conditioned fear, but not unconditioned fear to a predator odor | en_US |
| Type | Article | en_US |
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