Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia
| Author(s) | Khan, Saira | |
| Author(s) | Wolin, K. Y. | |
| Author(s) | Pakpahan, R. | |
| Author(s) | Grubb, R. L. III | |
| Author(s) | Colditz, G. A. | |
| Author(s) | Ragard, L. | |
| Author(s) | Mabie, J. | |
| Author(s) | Breyer, B. N. | |
| Author(s) | Andriole, G. L. | |
| Author(s) | Sutcliffe, S. | |
| Date Accessioned | 2023-10-11T19:08:22Z | |
| Date Available | 2023-10-11T19:08:22Z | |
| Publication Date | 2021-03-27 | |
| Description | This article was originally published in BMC Urology. The version of record is available at: https://doi.org/10.1186/s12894-021-00816-5 | |
| Abstract | Background Existing evidence suggests that there is an association between body size and prevalent Benign Prostatic Hyperplasia (BPH)-related outcomes and nocturia. However, there is limited evidence on the association between body size throughout the life-course and incident BPH-related outcomes. Methods Our study population consisted of men without histories of prostate cancer, BPH-related outcomes, or nocturia in the intervention arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) (n = 4710). Associations for body size in early- (age 20), mid- (age 50) and late-life (age ≥ 55, mean age 60.7 years) and weight change with incident BPH-related outcomes (including self-reported nocturia and physician diagnosis of BPH, digital rectal examination-estimated prostate volume ≥ 30 cc, and prostate-specific antigen [PSA] concentration > 1.4 ng/mL) were examined using Poisson regression with robust variance estimation. Results Men who were obese in late-life were 25% more likely to report nocturia (Relative Risk (RR): 1.25, 95% Confidence Interval (CI): 1.11–1.40; p-trendfor continuous BMI < 0.0001) and men who were either overweight or obese in late-life were more likely to report a prostate volume ≥ 30 cc (RRoverweight: 1.13, 95% CI 1.07–1.21; RRobese: 1.10, 95% CI 1.02–1.19; p-trendfor continuous BMI = 0.017) as compared to normal weight men. Obesity at ages 20 and 50 was similarly associated with both nocturia and prostate volume ≥ 30 cc. Considering trajectories of body size, men who were normal weight at age 20 and became overweight or obese by later-life had increased risks of nocturia (RRnormal to overweight: 1.09, 95% CI 0.98–1.22; RRnormal to obese: 1.28, 95% CI 1.10–1.47) and a prostate volume ≥ 30 cc (RRnormal to overweight: 1.12, 95% CI 1.05–1.20). Too few men were obese early in life to examine the independent effect of early-life body size. Later-life body size modified the association between physical activity and nocturia. Conclusions We found that later-life body size, independent of early-life body size, was associated with adverse BPH outcomes, suggesting that interventions to reduce body size even late in life can potentially reduce the burden of BPH-related outcomes and nocturia. | |
| Sponsor | This project was supported by the National Institute of Diabetes and Digestive and Kidney Diseases: R21DK090595. SK was supported by Department of Defense (PC170130; PI, Khan). SS was supported by Barnes-Jewish Hospital Foundation, the Alvin J. Siteman Cancer Center (NIH/NCI (P30 CA091842)), and the Institute for Clinical and Translational Sciences (NIH/NCATS (UL1 TR002345)). | |
| Citation | Khan, S., Wolin, K.Y., Pakpahan, R. et al. Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia. BMC Urol 21, 47 (2021). https://doi.org/10.1186/s12894-021-00816-5 | |
| ISSN | 1471-2490 | |
| URL | https://udspace.udel.edu/handle/19716/33535 | |
| Language | en_US | |
| Publisher | BMC Urology | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| Keywords | Benign Prostatic Hyperplasia (BPH) | |
| Keywords | body size | |
| Keywords | obesity | |
| Keywords | nocturia | |
| Keywords | prostate volume | |
| Keywords | PLCO | |
| Keywords | good health and well-being | |
| Title | Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia | |
| Type | Article |
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