Associations between cortical thickness and anxious/depressive symptoms differ by the quality of early care

Author(s)Korom, Marta
Author(s)Tottenham, Nim
Author(s)Valadez, Emilio A.
Author(s)Dozier, Mary
Date Accessioned2022-01-31T20:59:27Z
Date Available2022-01-31T20:59:27Z
Publication Date2021-10-22
DescriptionThis article was originally published in Development and Psychopathology. The version of record is available at: https://doi.org/10.1017/S0954579421000845en_US
AbstractA variety of childhood experiences can lead to anxious/depressed (A/D) symptoms. The aim of the present study was to explore the brain morphological (cortical thickness and surface area) correlates of A/D symptoms and the extent to which these phenotypes vary depending on the quality of the parenting context in which children develop. Structural magnetic resonance imaging (MRI) scans were acquired on 45 children with Child Protective Services (CPS) involvement due to risk of not receiving adequate care (high-risk group) and 25 children without CPS involvement (low-risk group) (rangeage = 8.08–12.14; M age = 10.05) to assess cortical thickness (CT) and cortical surface area (SA). A/D symptoms were measured using the Child Behavioral Checklist. The association between A/D symptoms and CT, but not SA, differed by risk status such that high-risk children showed decreasing CT as A/D scores increased, whereas low-risk children showed increasing CT as A/D scores increased. This interaction was specific to CT in prefrontal, frontal, temporal, and parietal cortical regions. The groups had marginally different A/D scores, in the direction of higher risk being associated with lower A/D scores. Results suggest that CT correlates of A/D symptoms are differentially shaped by the quality of early caregiving experiences and should be distinguished between high- and low-risk children.en_US
SponsorThis research was supported by the National Institute of Mental Health R01 R01MH074374-07S1 grant.en_US
CitationKorom, M., Tottenham, N., Valadez, E., & Dozier, M. (2021). Associations between cortical thickness and anxious/depressive symptoms differ by the quality of early care. Development and Psychopathology, 1-12. doi:10.1017/S0954579421000845en_US
ISSN1469-2198
URLhttps://udspace.udel.edu/handle/19716/30228
Languageen_USen_US
PublisherDevelopment and Psychopathologyen_US
Keywordsanxious/depressive symptomsen_US
Keywordscaregiving qualityen_US
Keywordscortical thicknessen_US
Keywordsearly adversityen_US
Keywordspial surface areaen_US
TitleAssociations between cortical thickness and anxious/depressive symptoms differ by the quality of early careen_US
TypeArticleen_US
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