Fluid Balance And Electrolyte Distribution In The Human Body
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Date
1965-02
Authors
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Journal ISSN
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Publisher
Rand Corporation
Abstract
Description
This
Memorandum presents a conceptual model and a
mathematical method for computing the physiological fluid
and electrolyte distribution for selected body compartments
of an average, young, 70-kilogram human male. The
mathematical procedure simulates the physiological subsystems
by incorporating all the known chemical reactions
and electrochemical relations which seem necessary to
establish the fluid and electrolyte distribution. Because
the whole body is being considered, the relatively large
number of computations required argues that a computer be
employed,
The construction of the model and the mathematical
background is given in heuristic form only, with reference
to earlier papers for rigorous development. However, considerable detail is shown regarding the analysis of the
computed results for a standard, steady-state, average,
young, resting, 70-kg human male. Finally, the results
of validation experiments, consisting of chemical stresses
applied to the model, are discussed. In some cases, these
results are compared with similar experiments in the biological
literature, but in others reference is made to a companion
paper by G. B. Bradham, et al. (1), in which
particular laboratory validation experiments are described
in detail. The results of these experiments indicate that
the model is a valid supplementary tool for research in
the clinical and the research laboratory as well as in
theoretical physiology.
Keywords
Fluid Balance, Electrolyte Distribution, Human Body