Improved slit-shaped microseparator and its integration with a microreactor for modular biomanufacturing

Author(s)Bhattacharyya, Souryadeep
Author(s)Desir, Pierre
Author(s)Prodinger, Sebastian
Author(s)Lobo, Raul F.
Author(s)Vlachos, Dionisios G.
Date Accessioned2022-01-26T19:11:08Z
Date Available2022-01-26T19:11:08Z
Publication Date2021-04-30
DescriptionThis article was originally published in Green Chemistry. The version of record is available at: https://doi.org/10.1039/D1GC00642Hen_US
AbstractModular and distributed biomanufacturing requires continuous flow microreactors integrated with efficient separation units operating at comparable time scales: biphasic reactive extraction of 5-hydroxymethyl furfural (HMF) by fructose dehydration is an excellent example. The liquid–liquid extraction (LLE) and fast reaction kinetics in biphasic microchannels can immensely benefit from a downstream microseparator enabling separation of an HMF-rich organic extract and an aqueous raffinate. Here we demonstrate the successful implementation of an effective slit-shaped microseparator for eleven organic-water biphasic systems. The microseparator successfully separates six of these over reasonable flow rates. The ratio of capillary and hydraulic pressures qualitatively rationalizes the separation performance, while a transition to non-segmented flow patterns correlates with performance deterioration. Acids and salts, integral parts of the chemistry, significantly expand the flow rates for efficient separation enabling a broader slate of organic solvents. For the MIBK/water biphasic system, we demonstrate perfect separation performance over a 16-fold variation in the organic to aqueous flow ratio. Here we also integrate the microseparator and extractive microreactor into a modular system and achieve an HMF yield of up to 93% – the highest reported fractional HMF productivity of 27.9 min−1 – at an ultrashort residence time of 2 s. This unprecedented performance is maintained over a 50-fold fructose concentration range and is stable with time-on-stream. This microseparator exhibits a ten-fold reduction in separation time and substantial energy savings over conventional decanters. As such, it holds promise for continuous process intensification and modular biomanufacturing.en_US
SponsorThis work was supported in part by the RAPID manufacturing institute via the Department of Energy (DOE) Advanced Manufacturing Office (AMO), award number DE-EE0007888-7.6. RAPID projects at the University of Delaware are also made possible in part by the State of Delaware's funding. The Delaware Energy Institute gratefully acknowledges the State of Delaware's support and partnership. We are grateful to Brian Brant (University of Delaware College of Engineering Machine Shop) for his support in fabricating the microseparator and holding rig.en_US
CitationBhattacharyya, Souryadeep, Pierre Desir, Sebastian Prodinger, Raul F. Lobo, and Dionisios G. Vlachos. 2021. “Improved Slit-Shaped Microseparator and Its Integration with a Microreactor for Modular Biomanufacturing.” Green Chem. 23 (10): 3700–3714. https://doi.org/10.1039/D1GC00642H.en_US
ISSN1463-9270
URLhttps://udspace.udel.edu/handle/19716/30121
Languageen_USen_US
PublisherGreen Chemistryen_US
TitleImproved slit-shaped microseparator and its integration with a microreactor for modular biomanufacturingen_US
TypeArticleen_US
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