Preliminary examination of the effects of an early parenting intervention on amygdala-orbitofrontal cortex resting-state functional connectivity among high-risk children: A randomized clinical trial
| Author(s) | Korom, Marta | |
| Author(s) | Valadez, Emilio A. | |
| Author(s) | Tottenham, Nim | |
| Author(s) | Dozier, Mary | |
| Author(s) | Spielberg, Jeffrey M. | |
| Date Accessioned | 2024-02-19T18:14:56Z | |
| Date Available | 2024-02-19T18:14:56Z | |
| Publication Date | 2024-01-22 | |
| Description | This article was originally published in Development and Psychopathology. The version of record is available at: https://doi.org/10.1017/S0954579423001669. © The Author(s), 2024. Published by Cambridge University Press | |
| Abstract | We examined the long-term causal effects of an evidence-based parenting program delivered in infancy on children’s emotion regulation and resting-state functional connectivity (rs-fc) during middle childhood. Families were referred to the study by Child Protective Services (CPS) as part of a diversion from a foster care program. A low-risk group of families was also recruited. CPS-involved families were randomly assigned to receive the target (Attachment and Biobehavioral Catch-up, ABC) or a control intervention (Developmental Education for Families, DEF) before infants turned 2. Both interventions were home-based, manualized, and 10-sessions long. During middle childhood, children underwent a 6-min resting-state functional MRI scan. Amygdala seed-based rs-fc analysis was completed with intervention group as the group-level predictor of interest. Fifty-seven children (NABC = 21; NDEF = 17; NCOMP = 19; Mage = 10.02 years, range = 8.08–12.14) were scanned successfully. The DEF group evidenced negative left amygdala↔OFC connectivity, whereas connectivity was near zero in the ABC and comparison groups (ABCvsDEF: Cohen’s d = 1.17). ABC may enhance high-risk children’s regulatory neurobiology outcomes ∼8 years after the intervention was completed. | |
| Sponsor | National Institute of Mental Health 3R01MH074374. | |
| Citation | Korom M, Valadez EA, Tottenham N, Dozier M, Spielberg JM. Preliminary examination of the effects of an early parenting intervention on amygdala-orbitofrontal cortex resting-state functional connectivity among high-risk children: A randomized clinical trial. Development and Psychopathology. Published online 2024:1-9. doi:10.1017/S0954579423001669 | |
| ISSN | 1469-2198 | |
| URL | https://udspace.udel.edu/handle/19716/34001 | |
| Language | en_US | |
| Publisher | Development and Psychopathology | |
| dc.rights | Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| Keywords | parenting intervention | |
| Keywords | imaging | |
| Keywords | resting-state | |
| Keywords | amygdala↔OFC functional connectivity | |
| Keywords | emotion regulation | |
| Keywords | adversity | |
| Title | Preliminary examination of the effects of an early parenting intervention on amygdala-orbitofrontal cortex resting-state functional connectivity among high-risk children: A randomized clinical trial | |
| Type | Article |
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