Combination cancer imaging and phototherapy mediated by membrane-wrapped nanoparticles

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Author(s)Aboeleneena, Sara B.
Author(s)Scully, Mackenzie A.
Author(s)Kramarenko, George C.
Author(s)Day, Emily S.
Date Accessioned2024-01-25T19:07:34Z
Date Available2024-01-25T19:07:34Z
Publication Date2023-10-30
DescriptionThis article was originally published in International Journal of Hyperthermia. The version of record is available at: https://doi.org/10.1080/02656736.2023.2272066. © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.
AbstractCancer is a devastating health problem with inadequate treatment options. Many conventional treatments for solid-tumor cancers lack tumor specificity, which results in low efficacy and off-target damage to healthy tissues. Nanoparticle (NP)-mediated photothermal therapy (PTT) is a promising minimally invasive treatment for solid-tumor cancers that has entered clinical trials. Traditionally, NPs used for PTT are coated with passivating agents and/or targeting ligands, but alternative coatings are being explored to enhance tumor specific delivery. In particular, cell-derived membranes have emerged as promising coatings that improve the biointerfacing of photoactive NPs, which reduces their immune recognition, prolongs their systemic circulation and increases their tumor accumulation, allowing for more effective PTT. To maximize treatment success, membrane-wrapped nanoparticles (MWNPs) that enable dual tumor imaging and PTT are being explored. These multifunctional theranostic NPs can be used to enhance tumor detection and/or ensure a sufficient quantity of NPs that have arrived in the tumor prior to laser irradiation. This review summarizes the current state-of-the-art in engineering MWNPs for combination cancer imaging and PTT and discusses considerations for the path toward clinical translation.
SponsorThis work was supported by the National Science Foundation (NSF) under grant number DMR1752009. Funding was also provided by the National Institutes of Health (NIH) under award number R01CA211925 and R35GM149292. GK acknowledges support from the graduate traineeship program NRT-HDR: Computing and Data Science Training for Materials Innovation, Discovery, Analytics (MIDAS) funded by NSF grant number 2125703.
CitationSara B. Aboeleneen, Mackenzie A. Scully, George C. Kramarenko & Emily S. Day (2023) Combination cancer imaging and phototherapy mediated by membrane-wrapped nanoparticles, International Journal of Hyperthermia, 40:1, DOI: 10.1080/02656736.2023.2272066
ISSN1464-5157
URLhttps://udspace.udel.edu/handle/19716/33924
Languageen_US
PublisherInternational Journal of Hyperthermia
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
KeywordsBiomimicry
Keywordsphotothermal therapy
Keywordstheranostic
Keywordsmultimodal imaging
Keywordsnanomedicine
Keywordshyperthermia
TitleCombination cancer imaging and phototherapy mediated by membrane-wrapped nanoparticles
TypeArticle
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