Associations between noninvasive upper- and lower-limb vascular function assessments: extending the evidence to young women

Author(s)D'Agata, Michele N.
Author(s)Hoopes, Elissa K.
Author(s)Witman, Melissa A.
Date Accessioned2022-10-05T13:13:57Z
Date Available2022-10-05T13:13:57Z
Publication Date2022-10-01
DescriptionThis article was originally published in Journal of Applied Physiology. The version of record is available at: This article will be embargoed until 10/01/2023.en_US
AbstractBrachial artery (BA) flow-mediated dilation (FMD) is a well-established measure of peripheral vascular function prognostic of future cardiovascular events. The vasodilatory response to FMD (FMD%) reflects upper-limb conduit artery function, whereas reactive hyperemia (RH) following cuff-occlusion release reflects upper-limb resistance artery function. Comparatively, passive leg movement (PLM) is a newer, increasingly utilized assessment of lower-limb resistance artery function. To increase its clinical utility, PLM-induced leg blood flow (LBF) responses have been compared with hemodynamic responses to FMD, but only in men. Therefore, the purpose of this study was to retrospectively compare LBF responses to FMD% and RH responses in women. We hypothesized that LBF responses would be positively associated with both FMD% and RH, but to a greater extent with RH. FMD and PLM were performed on 72 women (23 ± 4 yr). Arterial diameter and blood velocity were assessed using Doppler ultrasound. Pearson correlation coefficients were used to evaluate associations. Measures of resistance artery function were weakly positively associated: change in BA blood flow ΔBABF and ΔLBF (r = 0.33, P < 0.01), BABF area under the curve (BABF AUC) and LBF AUC (r = 0.33, P < 0.01), and BABFpeak and LBFpeak (r = 0.37, P < 0.01). However, FMD% was not associated with any index of PLM (all P > 0.30). In women, indices of resistance artery function in the upper- and lower limbs were positively associated. However, contrary to the previous work in men, upper-limb conduit artery function was not associated with lower-limb resistance artery function suggesting these assessments capture different aspects of vascular function and should not be used interchangeably in women. NEW & NOTEWORTHY: Upper- and lower-limb indices of resistance artery function are positively associated in young women when assessed by reactive hyperemia following brachial artery flow-mediated dilation (FMD) cuff-occlusion release and leg blood flow responses to passive leg movement (PLM), respectively. However, despite previous data demonstrating a positive association between upper-limb conduit artery function assessed by FMD and lower-limb resistance artery function assessed by PLM in young men, these measures do not appear to be related in young women.en_US
SponsorThis study was supported in part by NIH grants P20 GM113125and R01 HLI55764 (M.A.W).en_US
CitationD’Agata, Michele N., Elissa K. Hoopes, and Melissa A. Witman. “Associations between Noninvasive Upper- and Lower-Limb Vascular Function Assessments: Extending the Evidence to Young Women.” Journal of Applied Physiology 133, no. 4 (October 1, 2022): 886–92.
PublisherJournal of Applied Physiologyen_US
Keywordsflow-mediated dilationen_US
Keywordspassive leg movementen_US
Keywordsvascular functionen_US
Keywordsconduit artery functionen_US
Keywordsresistance artery functionen_US
TitleAssociations between noninvasive upper- and lower-limb vascular function assessments: extending the evidence to young womenen_US
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