Synthetic efforts toward the total synthesis of psiguadial A & HPLC method development for artemisinin metabolites
Date
2022
Authors
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Journal ISSN
Volume Title
Publisher
University of Delaware
Abstract
Chapter 1 outlines the diverse collection of natural products that are classified as meroterpenoid natural products. Taking a closer look at their biological background as well as the plant systems that produce these wonderful natural products. Secondary metabolites often effect organisms outside of the producing host, which lends to highly specialized small molecules that are synthesized by the plant species. It is this diversification that has led to exceptionally unique meroterpenoid natural products that offer an array of biological activity as well as cytoxicity towards human carcinoma cell lines. ☐ Chapter 2 outlines the prior and current effort on advancing the model system for the natural product psiguadial A. Previous efforts by Drs. Lewis, Wisthoff, and Zheng have offered a plethora of useful insights upon which the current model system efforts are based upon. The proposed current model system route includes a selective reduction of a conjugated diene to the mono-ene. ☐ Chapter 3 will focus on the current strategy toward the natural product psiguadial A based on investigations performed during the model system trials and efforts. ☐ Chapter 4 will focus on a collaboration between Prof. Bertrand and Prof. William J. Chain to transfer the entire metabolic pathway of Artemisia annua into the non-native species cassava in the hopes of lowering the high mortality rates associated with malaria due to inaccessibility to artemisinin.
Description
Keywords
Liver cancer research, Natural product, Organic synthesis, Psiguadial A, Total synthesis