Proteomic insight into human directed selection of the domesticated chicken Gallus gallus

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Author(s)Schmidt, Carl J.
Author(s)Kim, Dong Kyun
Author(s)Pendarvis, G Ken
Author(s)Abasht, Behnam
Author(s)McCarthy, Fiona M.
Date Accessioned2023-11-09T19:44:25Z
Date Available2023-11-09T19:44:25Z
Publication Date2023-08-07
DescriptionThis article was originally published in PLoS ONE. The version of record is available at: https://doi.org/10.1371/journal.pone.0289648. © 2023 Schmidt et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
AbstractChicken domestication began at least 3,500 years ago for purposes of divination, cockfighting, and food. Prior to industrial scale chicken production, domestication selected larger birds with increased egg production. In the mid-20th century companies began intensive selection with the broiler (meat) industry focusing on improved feed conversion, rapid growth, and breast muscle yield. Here we present proteomic analysis comparing the modern broiler line, Ross 708, with the UIUC legacy line which is not selected for growth traits. Breast muscle proteome analysis identifies cellular processes that have responded to human directed artificial selection. Mass spectrometry was used to identify protein level differences in the breast muscle of 6-day old chicks from Modern and Legacy lines. Our results indicate elevated levels of stress proteins, ribosomal proteins and proteins that participate in the innate immune pathway in the Modern chickens. Furthermore, the comparative analyses indicated expression differences for proteins involved in multiple biochemical pathways. In particular, the Modern line had elevated levels of proteins affecting the pentose phosphate pathway, TCA cycle and fatty acid oxidation while proteins involved in the first phase of glycolysis were reduced compared to the Legacy line. These analyses provide hypotheses linking the morphometric changes driven by human directed selection to biochemical pathways. These results also have implications for the poultry industry, specifically Wooden Breast disease which is linked to rapid breast muscle growth.
SponsorCJS was supported by the Agriculture and Food Research Institute competitive grant (2011-67003-30228) from the United States Department of Agriculture National Institute of Food and Agriculture The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
CitationSchmidt CJ, Kim DK, Pendarvis GK, Abasht B, McCarthy FM (2023) Proteomic insight into human directed selection of the domesticated chicken Gallus gallus. PLoS ONE 18(8): e0289648. https://doi.org/10.1371/journal.pone.0289648
ISSN1932-6203
URLhttps://udspace.udel.edu/handle/19716/33617
Languageen_US
PublisherPLoS ONE
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
Keywordsmuscle proteins
Keywordschickens
Keywordsbirds
Keywordsskeletal muscles
Keywordsmuscle protein synthesis
Keywordscitric acid cycle
Keywordsclycolysis
Keywordsphosphates
TitleProteomic insight into human directed selection of the domesticated chicken Gallus gallus
TypeArticle
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