Antifatigue and Anti-Inflammatory Effects of Cervus elaphus L., Angelica gigas Nakai, and Astragalus membranaceus Bunge Complex Extracts in Physically Fatigued Mice

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Author(s)Huang, Wen Yan
Author(s)Pan, Jeong Hoon
Author(s)Jeong, Inhye
Author(s)Oh, Seong Ju
Author(s)Hyun, Yong Geon
Author(s)Kim, Moon Seong
Author(s)Han, Bok Kyung
Author(s)Hong, Jiyoun
Author(s)Koo, Yong Tae
Author(s)Lee, Ki Won
Author(s)Jin, Bora
Author(s)Noh, Dongjin
Author(s)Kim, Sangho
Author(s)Kim, Jae Kyeom
Author(s)Shin, Eui-Cheol
Author(s)Kim, Young Jun
Date Accessioned2023-02-16T20:00:41Z
Date Available2023-02-16T20:00:41Z
Publication Date2022-12-12
DescriptionThis is the accepted version of the following article: Huang, Wen Yan, Jeong Hoon Pan, Inhye Jeong, Seong Ju Oh, Yong Geon Hyun, Moon Seong Kim, Bok Kyung Han, et al. “Antifatigue and Anti-Inflammatory Effects of Cervus Elaphus L., Angelica Gigas Nakai, and Astragalus Membranaceus Bunge Complex Extracts in Physically Fatigued Mice.” Journal of Medicinal Food 25, no. 12 (December 12, 2022): 1126–32. https://doi.org/10.1089/jmf.2022.K.0103, which has now been formally published in final form at https://doi.org/10.1089/jmf.2022.K.0103. This original submission version of the article may be used for non-commercial purposes in accordance with the Mary Ann Liebert, Inc., publishers’ self-archiving terms and conditions.
AbstractFatigue is a common complaint among people under stress, causing an array of negative effects on physical function. In this study, we investigated the antifatigue and anti-inflammatory effects of Cervus elaphus L., Angelica gigas Nakai, and Astragalus membranaceus Bunge complex extracts (CAA) using a treadmill stress test in animal models. The mice were administered various doses of CAA (50–200 mg/kg bw per day) once daily for 21 days. After exhaustive treadmill exercise, the running time of CAA-treated mice increased 1.5 times; fatigue-related biochemical parameters, including lactate dehydrogenase (∼30%), creatine kinase (∼20%), and proinflammatory cytokines interleukin (IL)-1β (∼10%), and IL-6 (∼10%) in the serum and muscle tissue were downregulated compared with those in exercised control mice. This study provides strong evidence for the prevention of CAA-induced inflammatory incidences mediated by the blockade of nuclear factor-κB activation. Collectively, our results indicate that CAA can alleviate symptoms of fatigue in mice as an effective anti-inflammatory agent.
SponsorThis study was supported by Kwangdong Pharmaceutical Co., Ltd., and a grant (Graduate School Education Program of Regulatory Sciences for Functional Food, 21153MFDS604) from Ministry of Food and Drug Safety of the Republic of Korea.
CitationHuang, Wen Yan, Jeong Hoon Pan, Inhye Jeong, Seong Ju Oh, Yong Geon Hyun, Moon Seong Kim, Bok Kyung Han, et al. “Antifatigue and Anti-Inflammatory Effects of Cervus Elaphus L., Angelica Gigas Nakai, and Astragalus Membranaceus Bunge Complex Extracts in Physically Fatigued Mice.” Journal of Medicinal Food 25, no. 12 (December 12, 2022): 1126–32. https://doi.org/10.1089/jmf.2022.K.0103.
ISSN1557-7600
URLhttps://udspace.udel.edu/handle/19716/32308
Languageen_US
PublisherJournal of Medicinal Food
KeywordsAngelica gigas Nakai
Keywordsantifatigue
Keywordsanti-inflammatory
KeywordsAstragalus membranaceus
KeywordsBunge
KeywordsCervus elaphus L
TitleAntifatigue and Anti-Inflammatory Effects of Cervus elaphus L., Angelica gigas Nakai, and Astragalus membranaceus Bunge Complex Extracts in Physically Fatigued Mice
TypeArticle
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