Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery
| Author(s) | Green, Matthew D. | |
| Author(s) | Foster, Abbygail A. | |
| Author(s) | Greco, Chad T. | |
| Author(s) | Roy, Raghunath | |
| Author(s) | Lehr, Rachel M. | |
| Author(s) | Epps, Thomas H. III | |
| Author(s) | Sullivan, Millicent O. | |
| Ordered Author | Matthew D. Green, Abbygail A. Foster, Chad T. Greco, Raghunath Roy, Rachel M. Lehr, Thomas H. Epps, III and Millicent O. Sullivan | |
| UD Author | Green, Matthew D. | en_US |
| UD Author | Foster, Abbygail A. | en_US |
| UD Author | Greco, Chad T. | en_US |
| UD Author | Roy, Raghunath | en_US |
| UD Author | Lehr, Rachel M. | en_US |
| UD Author | Epps, Thomas H. III | en_US |
| UD Author | Sullivan, Millicent O. | en_US |
| Date Accessioned | 2016-03-16T15:33:43Z | |
| Date Available | 2016-03-16T15:33:43Z | |
| Copyright Date | Copyright © The Royal Society of Chemistry 2014. | en_US |
| Publication Date | 2014-06-05 | |
| Description | Publisher's PDF | en_US |
| Abstract | Binding interactions between DNA and cationic nanocarriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and o-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to improved non-viral gene packaging. | en_US |
| Department | University of Delaware. Department of Chemical & Biomolecular Engineering. | en_US |
| Citation | Thomas III, H. "Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery." Polymer chemistry 5.19 (2014): 5535-5541. | en_US |
| DOI | DOI: 10.1039/C4PY00638K | en_US |
| ISSN | 1759-9954 ; e- 1759-9962 | en_US |
| URL | http://udspace.udel.edu/handle/19716/17509 | |
| Language | en_US | en_US |
| Publisher | Royal Society of Chemistry | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | Polymer Chemistry | en_US |
| dc.source.uri | http://www.rsc.org/journals-books-databases/about-journals/polymer-chemistry/ | en_US |
| Title | Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery | en_US |
| Type | Article | en_US |
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