Membrane-wrapped nanoparticles for nucleic acid delivery
| Author(s) | Scully, Mackenzie A. | |
| Author(s) | Sterin, Eric H. | |
| Author(s) | Day, Emily S. | |
| Date Accessioned | 2022-07-27T17:53:42Z | |
| Date Available | 2022-07-27T17:53:42Z | |
| Publication Date | 2022-06-29 | |
| Description | This article was originally published in Biomaterials Science. The version of record is available at: https://doi.org/10.1039/D2BM00447J. This article will be embargoed until 06/29/2023. | en_US |
| Abstract | There is an unmet need for carriers that can deliver nucleic acids (NAs) to cancer cells and tumors to perpetuate gene regulation and manage disease progression. Membrane-wrapped nanoparticles (NPs) can be loaded with exogenously designed nucleic acid cargoes, such as plasmid deoxyribonucleic acid (pDNA), messenger ribonucleic acid (mRNA), small interfering RNA (siRNA), microRNA (miRNA), and immunostimulatory CpG oligodeoxynucleotides (CpG ODNs), to mitigate challenges presented by NAs’ undesirable negative charge, hydrophilicity, and relatively large size. By conjugating or encapsulating NAs within membrane-wrapped NPs, various physiological barriers can be overcome so that NAs experience increased blood circulation half-lives and enhanced accumulation in intended sites. This review discusses the status of membrane-wrapped NPs as NA delivery vehicles and their advancement in gene regulation for cancer management in vitro and in vivo. With continued development, membrane-wrapped NPs have great potential as future clinical tools to treat cancer and other diseases with a known genetic basis. | en_US |
| Sponsor | Funding was provided by grants from the National Science Foundation (DMR-1752009) and National Institutes of Health (R35GM119659 and 1P20GM139760-1). The content is solely the responsibility of the authors and does not necessarily reflect the views of the funding agencies. | en_US |
| Citation | Scully, M. A., Sterin, E. H., & Day, E. S. (2022). Membrane-wrapped nanoparticles for nucleic acid delivery. Biomaterials Science, 10.1039.D2BM00447J. https://doi.org/10.1039/D2BM00447J | en_US |
| ISSN | 2047-4849 | |
| URL | https://udspace.udel.edu/handle/19716/31156 | |
| Language | en_US | en_US |
| Publisher | Biomaterials Science | en_US |
| Title | Membrane-wrapped nanoparticles for nucleic acid delivery | en_US |
| Type | Article | en_US |
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