Protein–DNA Interactions Regulate Human Papillomavirus DNA Replication, Transcription, and Oncogenesis
Date
2023-05-09
Journal Title
Journal ISSN
Volume Title
Publisher
International Journal of Molecular Sciences
Abstract
Human papillomavirus (HPV) is a group of alpha papillomaviruses that cause various illnesses, including cancer. There are more than 160 types of HPV, with many being “high-risk” types that have been clinically linked to cervical and other types of cancer. “Low-risk” types of HPV cause less severe conditions, such as genital warts. Over the past few decades, numerous studies have shed light on how HPV induces carcinogenesis. The HPV genome is a circular double-stranded DNA molecule that is approximately 8 kilobases in size. Replication of this genome is strictly regulated and requires two virus-encoded proteins, E1 and E2. E1 is a DNA helicase that is necessary for replisome assembly and replication of the HPV genome. On the other hand, E2 is responsible for initiating DNA replication and regulating the transcription of HPV-encoded genes, most importantly the E6 and E7 oncogenes. This article explores the genetic characteristics of high-risk HPV types, the roles of HPV-encoded proteins in HPV DNA replication, the regulation of transcription of E6 and E7 oncogenes, and the development of oncogenesis.
Description
This article was originally published in International Journal of Molecular Sciences. The version of record is available at: https://doi.org/10.3390/ijms24108493. © 2023 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords
HPV, cervical cancer, oropharyngeal cancer, E2 protein
Citation
Evande, Roxanne, Anshul Rana, Esther E. Biswas-Fiss, and Subhasis B. Biswas. 2023. "Protein–DNA Interactions Regulate Human Papillomavirus DNA Replication, Transcription, and Oncogenesis" International Journal of Molecular Sciences 24, no. 10: 8493. https://doi.org/10.3390/ijms24108493