A Review of IsomiRs in Colorectal Cancer

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Non-Coding RNA
As advancements in sequencing technology rapidly continue to develop, a new classification of microRNAs has occurred with the discovery of isomiRs, which are relatively common microRNAs with sequence variations compared to their established template microRNAs. This review article seeks to compile all known information about isomiRs in colorectal cancer (CRC), which has not, to our knowledge, been gathered previously to any great extent. A brief overview is given of the history of microRNAs, their implications in colon cancer, the canonical pathway of biogenesis and isomiR classification. This is followed by a comprehensive review of the literature that is available on microRNA isoforms in CRC. The information on isomiRs presented herein shows that isomiRs hold great promise for translation into new diagnostics and therapeutics in clinical medicine.
This article was originally published in Non-Coding RNA. The version of record is available at: https://doi.org/10.3390/ncrna9030034. © 2023 by the authors. Licensee MDPI, Basel, Switzerland.
colorectal cancer, microRNAs, isomiRs
Lausten, Molly A., and Bruce M. Boman. 2023. "A Review of IsomiRs in Colorectal Cancer" Non-Coding RNA 9, no. 3: 34. https://doi.org/10.3390/ncrna9030034