Closed-loop modeling of central and intrinsic cardiac nervous system circuits underlying cardiovascular control

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Author(s)Gee, Michelle M.
Author(s)Lenhoff, Abraham M.
Author(s)Schwaber, James S.
Author(s)Ogunnaike, Babatunde A.
Author(s)Vadigepalli, Rajanikanth
Date Accessioned2023-04-05T20:22:20Z
Date Available2023-04-05T20:22:20Z
Publication Date2023-03-21
DescriptionThis article was originally published in AIChE Journal. The version of record is available at: https://doi.org/10.1002/aic.18033. This work is in memory of Dr. Babatunde A. Ogunnaike, who co-advised Michelle M. Gee and guided the model development and analysis, and represents a milestone in the 30-year collaboration between Dr. Ogunnaike and Drs. Schwaber and Vadigepalli.
AbstractThe baroreflex is a multi-input, multi-output physiological control system that regulates blood pressure by modulating nerve activity between the brainstem and the heart. Existing computational models of the baroreflex do not explicitly incorporate the intrinsic cardiac nervous system (ICN), which mediates central control of heart function. We developed a computational model of closed-loop cardiovascular control by integrating a network representation of the ICN within central control reflex circuits. We examined central and local contributions to the control of heart rate, ventricular functions, and respiratory sinus arrhythmia (RSA). Our simulations match the experimentally observed relationship between RSA and lung tidal volume. Our simulations predicted the relative contributions of the sensory and the motor neuron pathways to the experimentally observed changes in the heart rate. Our closed-loop cardiovascular control model is primed for evaluating bioelectronic interventions to treat heart failure and renormalize cardiovascular physiology.
SponsorNational Heart, Lung, and Blood Institute, Grant/Award Numbers: R01 HL161696, U01 HL133360; National Science Foundation, Grant/Award Numbers: 1940700, OAC-1919839; NIH Office of the Director, Grant/Award Number: OT2 OD030534
CitationGee, MM, Lenhoff, AM, Schwaber, JS, Ogunnaike, BA, Vadigepalli, R. Closed-loop modeling of central and intrinsic cardiac nervous system circuits underlying cardiovascular control. AIChE J. 2023; 69( 4):e18033. doi:10.1002/aic.18033
ISSN1547-5905
URLhttps://udspace.udel.edu/handle/19716/32626
Languageen_US
PublisherAIChE Journal
Keywordsbaroreceptor reflex
Keywordsestimation and control in biological systems
Keywordsintrinsic cardiac nervous system
Keywordsphysiological modeling
Keywordsvagus nerve stimulation
TitleClosed-loop modeling of central and intrinsic cardiac nervous system circuits underlying cardiovascular control
TypeArticle
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