The UniProtKB guide to the human proteome

Advances in high-throughput and advanced technologies allow researchers to routinely perform whole genome and proteome analysis. For this purpose, they need high-quality resources providing comprehensive gene and protein sets for their organisms of interest. Using the example of the human proteome, we will describe the content of a complete proteome in the UniProt Knowledgebase (UniProtKB). We will show how manual expert curation of UniProtKB/Swiss-Prot is complemented by expert-driven automatic annotation to build a comprehensive, high-quality and traceable resource. We will also illustrate how the complexity of the human proteome is captured and structured in UniProtKB.
Publisher's PDF
Breuza, L., Poux, S., Estreicher, A., Famiglietti, M. L., Magrane, M., Tognolli, M., UniProt Consortium. (2016). The UniProtKB guide to the human proteome. Database-the Journal of Biological Databases and Curation, , bav120. doi:10.1093/database/bav120