The UniProtKB guide to the human proteome

Abstract
Advances in high-throughput and advanced technologies allow researchers to routinely perform whole genome and proteome analysis. For this purpose, they need high-quality resources providing comprehensive gene and protein sets for their organisms of interest. Using the example of the human proteome, we will describe the content of a complete proteome in the UniProt Knowledgebase (UniProtKB). We will show how manual expert curation of UniProtKB/Swiss-Prot is complemented by expert-driven automatic annotation to build a comprehensive, high-quality and traceable resource. We will also illustrate how the complexity of the human proteome is captured and structured in UniProtKB.
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Citation
Breuza, L., Poux, S., Estreicher, A., Famiglietti, M. L., Magrane, M., Tognolli, M., UniProt Consortium. (2016). The UniProtKB guide to the human proteome. Database-the Journal of Biological Databases and Curation, , bav120. doi:10.1093/database/bav120