Browsing by Author "Huang, Wen Yan"
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Item Antifatigue and Anti-Inflammatory Effects of Cervus elaphus L., Angelica gigas Nakai, and Astragalus membranaceus Bunge Complex Extracts in Physically Fatigued Mice(Journal of Medicinal Food, 2022-12-12) Huang, Wen Yan; Pan, Jeong Hoon; Jeong, Inhye; Oh, Seong Ju; Hyun, Yong Geon; Kim, Moon Seong; Han, Bok Kyung; Hong, Jiyoun; Koo, Yong Tae; Lee, Ki Won; Jin, Bora; Noh, Dongjin; Kim, Sangho; Kim, Jae Kyeom; Shin, Eui-Cheol; Kim, Young JunFatigue is a common complaint among people under stress, causing an array of negative effects on physical function. In this study, we investigated the antifatigue and anti-inflammatory effects of Cervus elaphus L., Angelica gigas Nakai, and Astragalus membranaceus Bunge complex extracts (CAA) using a treadmill stress test in animal models. The mice were administered various doses of CAA (50–200 mg/kg bw per day) once daily for 21 days. After exhaustive treadmill exercise, the running time of CAA-treated mice increased 1.5 times; fatigue-related biochemical parameters, including lactate dehydrogenase (∼30%), creatine kinase (∼20%), and proinflammatory cytokines interleukin (IL)-1β (∼10%), and IL-6 (∼10%) in the serum and muscle tissue were downregulated compared with those in exercised control mice. This study provides strong evidence for the prevention of CAA-induced inflammatory incidences mediated by the blockade of nuclear factor-κB activation. Collectively, our results indicate that CAA can alleviate symptoms of fatigue in mice as an effective anti-inflammatory agent.