Browsing by Author "Flynn, James"
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Item Self-Assembly, Self-Folding, and Origami: Comparative Design Principles(Biomimetics, 2022-12-27) Jungck, John R.; Brittain, Stephen; Plante, Donald; Flynn, JamesSelf-assembly is usually considered a parallel process while self-folding and origami are usually considered to be serial processes. We believe that these distinctions do not hold in actual experiments. Based upon our experience with 4D printing, we have developed three additional hybrid classes: (1) templated-assisted (tethered) self-assembly: e.g., when RNA is bound to viral capsomeres, the subunits are constricted in their interactions to have aspects of self-folding as well; (2) self-folding can depend upon interactions with the environment; for example, a protein synthesized on a ribosome will fold as soon as peptides enter the intracellular environment in a serial process whereas if denatured complete proteins are put into solution, parallel folding can occur simultaneously; and, (3) in turbulent environments, chaotic conditions continuously alternate processes. We have examined the 43,380 Dürer nets of dodecahedra and 43,380 Dürer nets of icosahedra and their corresponding duals: Schlegel diagrams. In order to better understand models of self-assembly of viral capsids, we have used both geometric (radius of gyration, convex hulls, angles) and topological (vertex connections, leaves, spanning trees, cutting trees, and degree distributions) perspectives to develop design principles for 4D printing experiments. Which configurations fold most rapidly? Which configurations lead to complete polyhedra most of the time? By using Hamiltonian circuits of the vertices of Dürer nets and Eulerian paths of cutting trees of polyhedra unto Schlegel diagrams, we have been able to develop a systematic sampling procedure to explore the 86,760 configurations, models of a T1 viral capsid with 60 subunits and to test alternatives with 4D printing experiments, use of MagformsTM, and origami models to demonstrate via movies the five processes described above.Item Successful Transitions Initiative: Delaware Youth Opportunities Initiative(2011-09) Flynn, James; Ospanova, Gauhar; Moreland, LisaIn September 2011, former Delaware Governor Ruth Ann Minner and the Policy Consensus Initiative (PCI ) — a national, nonpartisan, nonprofit organization working with leaders to create collaborative processes and harness resources from public, private, and civic centers — contracted with IPA to facilitate and provide coordinating services for their Successful Transitions Initiative (STI). This report documents the key phases of STI’s development to date: from its inception, initiated and funded by PCI and Governor Minner, to its merging with other concurrent activities and subsequent transformation as a true collaboration among partners working toward a statewide comprehensive implementation plan that addresses the needs of and improves the outcomes for Delaware’s transitioning youth. This report documents the key phases of STI’s development to date: from its inception, initiated and funded by PCI and Governor Minner, to its merging with other concurrent activities and subsequent transformation as a true collaboration among partners working toward a statewide comprehensive implementation plan that addresses the needs of and improves the outcomes for Delaware’s transitioning youth.