MRI-based measurement of in vivo disc mechanics in a young population due to flexion, extension, and diurnal loading

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Author(s)Meadows, Kyle D.
Author(s)Peloquin, John M.
Author(s)Newman, Harrah R.
Author(s)Cauchy, Peter J. K.
Author(s)Vresilovic, Edward J.
Author(s)Elliott, Dawn M.
Date Accessioned2023-03-21T17:50:38Z
Date Available2023-03-21T17:50:38Z
Publication Date2023-01-09
DescriptionThis article was originally published in JOR Spine. The version of record is available at: https://doi.org/10.1002/jsp2.1243
AbstractBackground: Intervertebral disc degeneration is often implicated in low back pain; however, discs with structural degeneration often do not cause pain. It may be that disc mechanics can provide better diagnosis and identification of the pain source. In cadaveric testing, the degenerated disc has altered mechanics, but in vivo, disc mechanics remain unknown. To measure in vivo disc mechanics, noninvasive methods must be developed to apply and measure physiological deformations. Aim: Thus, this study aimed to develop methods to measure disc mechanical function via noninvasive MRI during flexion and extension and after diurnal loading in a young population. This data will serve as baseline disc mechanics to later compare across ages and in patients. Materials & Methods: To accomplish this, subjects were imaged in the morning in a reference supine position, in flexion, in extension, and at the end of the day in a supine position. Disc deformations and vertebral motions were used to quantify disc axial strain, changes in wedge angle, and anterior–posterior (A-P) shear displacement. T2 weighted MRI was also used to evaluate disc degeneration via Pfirrmann grading and T2 time. All measures were then tested for effect of sex and disc level. Results: We found that flexion and extension caused level-dependent strains in the anterior and posterior of the disc, changes in wedge angle, and A-P shear displacements. Flexion had higher magnitude changes overall. Diurnal loading did not cause level-dependent strains but did cause small level-dependent changes in wedge angle and A-P shear displacements. Discussion: Correlations between disc degeneration and mechanics were largest in flexion, likely due to the smaller contribution of the facet joints in this condition. Conclusion: In summary, this study established methods to measure in vivo disc mechanical function via noninvasive MRI and established a baseline in a young population that may be compared to older subjects and clinical disorders in the future.
SponsorThis study was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (Grant number: 5R01AR050052) and the National Institute of General Medical Sciences (Grant number: 2P20GM103653).
CitationMeadows, K. D., Peloquin, J. M., Newman, H. R., Cauchy, P. J. K., Vresilovic, E. J., & Elliott, D. M. (2023). MRI-based measurement of in vivo disc mechanics in a young population due to flexion, extension, and diurnal loading. JOR Spine, e1243. https://doi.org/10.1002/jsp2.1243
ISSN2572-1143
URLhttps://udspace.udel.edu/handle/19716/32543
Languageen_US
PublisherJOR Spine
Keywordsbending
Keywordsdisc mechanical function
Keywordsdiurnal
Keywordsintervertebral disc
KeywordsMRI
KeywordsT2
Keywordsin vivo
TitleMRI-based measurement of in vivo disc mechanics in a young population due to flexion, extension, and diurnal loading
TypeArticle
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