Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery
Date
2014-06-05
Journal Title
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Abstract
Binding interactions between DNA and cationic nanocarriers must be
sufficiently strong to prevent nuclease-mediated degradation, yet
weak enough to permit transcription. We demonstrate cationic
diblock copolymers containing PEG and o-nitrobenzyl moieties that
facilitated tailorable DNA complexation and light-activated release.
This design unlocks a new approach to improved non-viral gene
packaging.
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Citation
Thomas III, H. "Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery." Polymer chemistry 5.19 (2014): 5535-5541.