Green, Matthew D.Foster, Abbygail A.Greco, Chad T.Roy, RaghunathLehr, Rachel M.Epps, Thomas H. IIISullivan, Millicent O.2016-03-162016-03-16Copyright2014-06-05Thomas III, H. "Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery." Polymer chemistry 5.19 (2014): 5535-5541.1759-9954 ; e- 1759-9962http://udspace.udel.edu/handle/19716/17509Publisher's PDFBinding interactions between DNA and cationic nanocarriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and o-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to improved non-viral gene packaging.en-USArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.ArticleDOI: 10.1039/C4PY00638K