Effects of prebiotics, probiotics, and synbiotics on the infant gut microbiota and other health outcomes: A systematic review
| Author(s) | Ferro, Lynn E. | |
| Author(s) | Crowley, Liana N. | |
| Author(s) | Bittinger, Kyle | |
| Author(s) | Friedman, Elliot S. | |
| Author(s) | Decker, Jessica E. | |
| Author(s) | Russel, Kathryn | |
| Author(s) | Katz, Sarah | |
| Author(s) | Kim, Jae Kyeom | |
| Author(s) | Trabulsi, Jillian C. | |
| Date Accessioned | 2022-03-14T17:21:02Z | |
| Date Available | 2022-03-14T17:21:02Z | |
| Publication Date | 2022-01-04 | |
| Description | This is an Accepted Manuscript of an article published by Taylor & Francis in Critical Reviews in Food Science and Nutrition on 01/04/2022, available online: http://www.tandfonline.com/10.1080/10408398.2021.2022595. This article will be embargoed until 01/04/2023. | en_US |
| Abstract | The primary aim of this review was to systematically evaluate the literature regarding the effect of pre-, pro-, or synbiotic supplementation in infant formula on the gastrointestinal microbiota. The Cochrane methodology for systematic reviews of randomized controlled trials (RCTs) was employed. Five databases were searched and 32 RCTs (2010–2021) were identified for inclusion: 20 prebiotic, 6 probiotic, and 6 synbiotic. The methods utilized to evaluate gastrointestinal microbiota varied across studies and included colony plating, fluorescence in situ hybridization, quantitative real-time polymerase chain reaction, or tagged sequencing of the 16S rRNA gene. Fecal Bifidobacterium levels increased with supplementation of prebiotics and synbiotics but not with probiotics alone. Probiotic and synbiotic supplementation generally increased fecal levels of the bacterial strain supplemented in the formula. Across all pre-, pro-, and synbiotic-supplemented formulas, results were inconsistent regarding fecal Clostridium levels. Fecal pH was lower with some prebiotic and synbiotic supplementation; however, no difference was seen with probiotics. Softer stools were often reported in infants supplemented with pre- and synbiotics, yet results were inconsistent for probiotic-supplemented formula. Limited evidence demonstrates that pre- and synbiotic supplementation increases fecal Bifidobacterium levels. Future studies utilizing comprehensive methodologies and additional studies in probiotics and synbiotics are warranted. | en_US |
| Sponsor | J.T. consults for Byheart, Inc. on infant nutrition clinical trial design. E.S.F consults for Astarte Medical and Enzymetrics Biosciences. This work was supported in part by the National Institutes of Health grant HD094908. | en_US |
| Citation | Lynn E. Ferro, Liana N. Crowley, Kyle Bittinger, Elliot S. Friedman, Jessica E. Decker, Kathryn Russel, Sarah Katz, Jae Kyeom Kim & Jillian C. Trabulsi (2022) Effects of prebiotics, probiotics, and synbiotics on the infant gut microbiota and other health outcomes: A systematic review, Critical Reviews in Food Science and Nutrition, DOI: 10.1080/10408398.2021.2022595 | en_US |
| ISSN | 1549-7852 | |
| URL | https://udspace.udel.edu/handle/19716/30644 | |
| Language | en_US | en_US |
| Publisher | Critical Reviews in Food Science and Nutrition | en_US |
| Keywords | Gastrointestinal microbiota | en_US |
| Keywords | infant | en_US |
| Keywords | prebiotic | en_US |
| Keywords | probiotic | en_US |
| Keywords | synbiotic | en_US |
| Keywords | systematic review | en_US |
| Title | Effects of prebiotics, probiotics, and synbiotics on the infant gut microbiota and other health outcomes: A systematic review | en_US |
| Type | Article | en_US |
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