Sequestration of gene products by decoys enhances precision in the timing of intracellular events
| Author(s) | Biswas, Kuheli | |
| Author(s) | Dey, Supravat | |
| Author(s) | Singh, Abhyudai | |
| Date Accessioned | 2024-11-22T18:36:48Z | |
| Date Available | 2024-11-22T18:36:48Z | |
| Publication Date | 2024-11-08 | |
| Description | This article was originally published in Scientific Reports. The version of record is available at: https://doi.org/10.1038/s41598-024-75505-y. © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. | |
| Abstract | Expressed gene products often interact ubiquitously with binding sites at nucleic acids and macromolecular complexes, known as decoys. The binding of transcription factors (TFs) to decoys can be crucial in controlling the stochastic dynamics of gene expression. Here, we explore the impact of decoys on the timing of intracellular events, as captured by the time taken for the levels of a given TF to reach a critical threshold level, known as the first passage time (FPT). Although nonlinearity introduced by binding makes exact mathematical analysis challenging, employing suitable approximations and reformulating FPT in terms of an alternative variable, we analytically assess the impact of decoys. The stability of the decoy-bound TFs against degradation impacts FPT statistics crucially. Decoys reduce noise in FPT, and stable decoy-bound TFs offer greater timing precision with less expression cost than their unstable counterparts. Interestingly, when both bound and free TFs decay at the same rate, decoy binding does not directly alter FPT noise. We verify these results by performing exact stochastic simulations. These results have important implications for the precise temporal scheduling of events involved in the functioning of biomolecular clocks, development processes, cell-cycle control, and cell-size homeostasis. | |
| Citation | Biswas, K., Dey, S. & Singh, A. Sequestration of gene products by decoys enhances precision in the timing of intracellular events. Sci Rep 14, 27199 (2024). https://doi.org/10.1038/s41598-024-75505-y | |
| ISSN | 2045-2322 | |
| URL | https://udspace.udel.edu/handle/19716/35617 | |
| Language | en_US | |
| Publisher | Scientific Reports | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| Title | Sequestration of gene products by decoys enhances precision in the timing of intracellular events | |
| Type | Article |
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