Legionella pneumophila Encodes a Peptidoglycan Recycling Machinery Critical for Survival within Macrophages

Abstract

We are thankful for support from the Delaware COBRE program, supported by a grant from the National Institute of General Medical Sciences (NIGMS 1 P30 GM110758 and 1 P20 GM104316-01A1). This work was supported by the NIH (U01 CA221230, R21 AI163949, R01 R01AI191445 (to CLG), R01 GM132460 (to JMF), and DP2HL152424 Kloxin). Additionally, the authors acknowledge the use of facilities and instrumentation supported by the National Science Foundation through the University of Delaware Materials Research Science and Engineering Center (DMR-2011824) and the NIH National Institute of General Medical Sciences (NIGMS) through the Delaware COBRE (P20GM104316, P30GM159572). We would like to thank Jeff Caplan and the Delaware Biotechnology Institute Bioimaging Center, where microscopy access was supported by grants from the NIH-NIGMS (P20 GM103446), the NIGMS (P20 GM139760), and the State of Delaware. We would also like to thank William Trout, Shi Bai and the UD NMR facility, as well as PapaNii Asare-Okai, from the UD Mass Spectrometry Core Facility. C.L.G. thanks the Dreyfus Foundation for support. M.E.R., M.P.V., S.N.H., A.W. and A.S.H. would like to thank the NIH for support through the Chemistry−Biology Interface (CBI) training grant, T32GM133395. Figures were created using Bio Render which was supported via a license provided to RN and CLG via the Delaware INBRE Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Description

This article was originally published in ACS Infectious Diseases. The version of record is available at: https://doi.org/10.1021/acsinfecdis.6c00053 © 2026 The Authors. Published by American Chemical Society

Citation

"Ratna, S., Acharya, A., Roland, M. E., Vasconcelos, M. P., Carnahan, B. R., Wang, A., Ghosh, A., Bolt, A., Ellis, J., Hyland, S. N., Hillman, A. S., Fox, J. M., Kloxin, A. M., Neunuebel, M. R., & Grimes, C. L. (2026). Legionella pneumophila Encodes a Peptidoglycan Recycling Machinery Critical for Survival within Macrophages. ACS Infectious Diseases. https://doi.org/10.1021/acsinfecdis.6c00053 "

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