Segregation Distortion In An F2 Population May Not Be Trasmitted In A Multi-Parental Population That Included The Same Parents
| Author(s) | Winkeler, Julia | |
| Date Accessioned | 2016-09-19T17:59:05Z | |
| Date Available | 2016-09-19T17:59:05Z | |
| Publication Date | 2016-05 | |
| Abstract | This study concerns the analysis of responsive allelic variation associated with phenotypic change. Examination of selection response through the lens of allele frequency change, a common approach for associating regions of a genome with changes in phenotypes, may be biased by non-random segregation or segregation distortion. That is, specific alleles appearing to change rapidly in frequency in a population could be due to distortion; however, these alleles may not be important drivers for the observed selection response (i.e. a false positive association). I have begun examining genetic properties of F2 populations derived from the initial crosses of a TROPICal Synthetic (TROPICS) population of maize. Here, I present results from one cross, CML341 x CML373, for which I constructed a genetic map from genotyping-by-sequencing marker data that showed near perfect chromosomal localization relative to the physical map. About 80% of the markers across the genome displayed higher levels of heterozygosity than expected but 98.6% of these did not exhibit statistically significant deviation; thus, there was significance in the total number of markers that exhibited deviation. Non-random distortion was found in multiple genomic regions that did not co-localize with previously mapped gametophytic or gametic factors in maize that are known to underlie distortion. The methods from this study will be used to examine the remaining F2 populations corresponding to parents of the TROPICS in order to inform analyses on allele frequency change in this population. | en_US |
| Advisor | Randall Wisser | |
| Program | Plant Science | |
| URL | http://udspace.udel.edu/handle/19716/19631 | |
| Publisher | University of Delaware | en_US |
| Keywords | plant science | en_US |
| Keywords | segregation distortion | en_US |
| Title | Segregation Distortion In An F2 Population May Not Be Trasmitted In A Multi-Parental Population That Included The Same Parents | en_US |
| Type | Thesis | en_US |