NeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae

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dc.contributor.authorKonrad, Kalin D.
dc.contributor.authorSong, Jia L.
dc.date.accessioned2023-02-09T15:25:11Z
dc.date.available2023-02-09T15:25:11Z
dc.date.issued2022-11-15
dc.descriptionThis article was originally published in microPublication Biology. The version of record is available at: https://doi.org/10.17912/micropub.biology.000682
dc.description.abstractNeuroD1 is a transcription factor (TF) that plays a dual role in vertebrate neurogenesis and glucose homeostasis in the pancreas. We identified a NeuroD1 antibody developed against human that cross-reacts with the sea urchin NeuroD1. NeuroD1 protein localizes to the presumptive ganglia and neurofilament structures in the ciliary band of the sea urchin larvae. In addition, we also observed NeuroD1 in the perinuclear region in the sea urchin gut which is analogous to the mammalian pancreas. These results suggest that NeuroD1 may play an evolutionarily conserved role in the invertebrate sea urchin.
dc.description.sponsorshipThis work is funded by National Science Foundation (IOS 1553338 and MCB 2103453 to J.L.S.), NIH P20GM103653, NIH NIGMS P20GM103446, and Sigma Xi Grants-in-Aid of Research (G2018031596227966 to K.D.K.).
dc.identifier.citationKonrad, KD; Song, JL (2022). NeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae. microPublication Biology. 10.17912/micropub.biology.000682.
dc.identifier.issn2578-9430
dc.identifier.urihttps://udspace.udel.edu/handle/19716/32255
dc.language.isoen_US
dc.publishermicroPublication Biology
dc.titleNeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae
dc.typeArticle

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