Inflammatory Breast Cancer: What’s in a Name?
Date
2025-09-25
Journal Title
Journal ISSN
Volume Title
Publisher
Medical Research Archives
Abstract
One of the most unique and highly aggressive types of cancer is known to be Inflammatory Breast Cancer. IBC is a distinct locally advanced breast cancer with a highly virulent course and extremely low 5- and 10-year survival rates. Although Inflammatory Breast Cancer only accounts for 1-3% of breast cancers it is estimated to account for 10% of breast cancer deaths annually in the United States. The accuracy of diagnosis and classification of this unique cancer is a major concern within patient and medical communities. This in turn has led to a strong advocacy movement. Historically, Inflammatory Breast Cancer was thought to be many different diseases but 100 years ago was defined as a unified disease. Over the past three decades several molecular studies have identified unique gene and protein signatures that make Inflammatory Breast Cancer a truly distinct entity. Despite this, the potential for inaccurate diagnosis and misclassification in cases of Inflammatory Breast Cancer is increased by many factors including its physical presentation.
Description
This article was originally published in Medical Research Archives. The version of record is available at: https://doi.org/10.18103/mra.v13i10.6962
© 2025 European Society of Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
Keywords
Inflammatory breast cancer, metastasis, tumor emboli, dermal lymphatics, stem cells, advocacy, miRNA
Citation
Aquino, H., & van Golen, K. (2025). Inflammatory Breast Cancer: What’s in a Name?. Medical Research Archives, 13(9). doi:10.18103/mra.v13i9.6962