MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
Date
2024-12-09
Journal Title
Journal ISSN
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Publisher
Nucleic Acids Research
Abstract
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015. Since its conception, MIBiG has been regularly updated to expand data coverage and remain up to date with innovations in natural product research. Here, we describe MIBiG version 4.0, an extensive update to the data repository and the underlying data standard. In a massive community annotation effort, 267 contributors performed 8304 edits, creating 557 new entries and modifying 590 existing entries, resulting in a new total of 3059 curated entries in MIBiG. Particular attention was paid to ensuring high data quality, with automated data validation using a newly developed custom submission portal prototype, paired with a novel peer-reviewing model. MIBiG 4.0 also takes steps towards a rolling release model and a broader involvement of the scientific community. MIBiG 4.0 is accessible online at https://mibig.secondarymetabolites.org/.
Graphical Abstract available at: https://doi.org/10.1093/nar/gkae1115.
Description
Please see the publication for a complete list of co-authors. This article was originally published in Nucleic Acids Research. The version of record is available at: https://doi.org/10.1093/nar/gkae1115.
The first two authors should be regarded as Joint First Authors.
© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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Citation
Zdouc, Mitja M, Kai Blin, Nico L L Louwen, Jorge Navarro, Catarina Loureiro, Chantal D Bader, Constance B Bailey, et al. “MIBiG 4.0: Advancing Biosynthetic Gene Cluster Curation through Global Collaboration.” Nucleic Acids Research, December 9, 2024, gkae1115. https://doi.org/10.1093/nar/gkae1115.