Body Composition and Behavior: Metabolic Implications of Birth via Cesarean Section in Prairie Vole (Microtus ochrogaster)

Author(s)Starr, Alexandra
Date Accessioned2022-10-11T13:30:44Z
Date Available2022-10-11T13:30:44Z
Publication Date2022-05
AbstractThroughout the United States the rates of performed cesarean section (CS) have increased. The scientific community has observed an association between birth by cesarean and the offspring's increased weight at maturity (Masukume, 2019). Studies are being conducted to better understand the relationship between cesarean delivery and offspring metabolism (Kozhimannil, 2013; Kenkel, 2020). To test this potential connection, a diet intervention study has been used to test vaginal delivery (VD) vs CS birth subject’s weight gain using a prairie vole model. Vole diets were either supplemented with a high-fat alternative mixed chow (MC) or fed standard vole chow (VC) to induce weight gain. Through this study, we collected sucrose preference, home cage, food consumption data from both birth mode groups and diet conditions. At sacrifice, we collected measures of weight, length, and adipose tissue to analyze for post mortem body composition in adulthood of each group. CS voles gained more weight than VD voles, despite having lower food consumption and greater locomotive activity. Body composition analysis found that CS animals were longer and heavier than their VD counterparts. Additionally, CS animals were found to have a larger percent brown adipose tissue relative to body weight compared to VD counterparts. Future studies will target the variables contributing to this weight gain among CS offspring by examining factors like muscle mass, and total adiposity through advanced imaging data. Future studies will incorporate exogenous oxytocin administration to examine the impact of birth mode on body weight, metabolism, adiposity, and later life development to determine the possible mechanisms impacting the metabolic outcomes seen in this study.en_US
AdvisorWilliam Kenkel
ProgramNeuroscience
URLhttps://udspace.udel.edu/handle/19716/31461
PublisherUniversity of Delawareen_US
KeywordsCesarean sectionen_US
KeywordsPrairie voleen_US
KeywordsBody compositionen_US
KeywordsMetabolismen_US
TitleBody Composition and Behavior: Metabolic Implications of Birth via Cesarean Section in Prairie Vole (Microtus ochrogaster)en_US
TypeThesisen_US
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