Hypoplastic left heart syndrome: Component models for cardiovascular systems after the Norwood procedure
| Author(s) | Abernethy, Shawn | |
| Date Accessioned | 2014-02-20T16:20:40Z | |
| Date Available | 2014-02-20T16:20:40Z | |
| Publication Date | 2013 | |
| Abstract | The goal of the Norwood procedure is to provide systemic circulation in a cardiovascular system with a single ventricle. This procedure is universally performed on the patient population of newborns with a underdeveloped left ventricle, Hypoplastic Left Heart Syndrome (HLHS). Two alternative surgical methods are employed to provide the pulmonary circulation, Right Ventricle-Pulmonary Artery Conduit method and the Blalock-Taussig Shunt method. The objective of this study is to take a previous compartment model of the two cardiovascular systems, verify the physiology and accuracy of the system of ordinary differential equations, implement a simulator based on the mathematical model, and evaluate the model's capacity to produce a realistic right ventricular pressure-volume loop. A MATLAB based software tool was written to model both procedures and provide a graphical user interface for others in clinical practice. An optimizer was used to adjust the parameters in order to produce a pressure-volume loop comparable to expectations. Once a reasonable P-V loop was obtained for each model, the physiological realism of the model was analyzed to discover its validity and limitations. | en_US |
| Advisor | Driscoll, Tobin A. | |
| Degree | M.S. | |
| Department | University of Delaware, Department of Applied Mathematics | |
| DOI | https://doi.org/10.58088/pya1-de39 | |
| URL | http://udspace.udel.edu/handle/19716/12862 | |
| Publisher | University of Delaware | en_US |
| dc.subject.lcsh | Heart -- Left ventricle -- Surgery -- Computer simulation. | |
| dc.subject.lcsh | Heart -- Left ventricle -- Surgery -- Mathematical models. | |
| dc.subject.lcsh | Cardiovascular system -- Computer simulation. | |
| dc.subject.lcsh | Cardiovascular system -- Mathematical models. | |
| Title | Hypoplastic left heart syndrome: Component models for cardiovascular systems after the Norwood procedure | en_US |
| Type | Thesis | en_US |