Hydrogenolysis of substituted cyclopropyl methyl acetates

Abstract

A methodology was developed for hydrogenolysis of protected, substituted, cyclopropyl methyl acetates. Ring opening conditions were determined by 'tuning' of the reaction media by its permittivity value. Acidic conditions led to different selectivity of ring-opened products than non-acidic conditions. Incorporation of aqueous media facilitated increased formation of ring-opened products. Ligands determined rate of ring-opened product formation in aqueous conditions.