Emerging Natural and Synthetic Compounds in the Management of Diabetic Neuropathy: Targeting Oxidative Stress and Inflammation
Date
2024-06-30
Journal Title
Journal ISSN
Volume Title
Publisher
Annals of Multidisciplinary Research, Innovation and Technology
Abstract
Diabetic neuropathy (DN) is a prevalent and threatening complication of diabetes, characterized by nerve damage resulting from chronic hyperglycemic conditions. Key factor in the pathogenesis of DN includes oxidative stress and inflammation, contributes to cellular damage (CD). Oxidative stress, chromatized by imbalance between pro-oxidants and antioxidants, leads to CD, while inflammation driven by pro-inflammatory cytokines, exacerbates the damage. Various factors, such as hyperglycemia-induced DNA damage, activation of transcription factors like NF-kB and Nrf2, and dysregulation of cytokine production contribute to the progression of DN. In this context, natural products and/or synthesized small molecules have garnered attention for their potential in mitigating oxidative stress and inflammation in DN. Natural products and synthesized small molecules have garnered attention for their potential in mitigrating oxidative stress and inflammation in DN. Compounds like sulforaphane, mangiferin, calpain, quercetin, curcumin, and resveratrol exhibit antioxidant and anti-inflammatory properties, thus showing promise in alleviating DN symptoms. Furthermore, various small molecules and herbal extracts have demonstrated efficacy in reducing oxidative stress, modulating cytokine levels, and improving nerve function in experimental models of DN. Combination therapies targeting multiple pathways involved in DN pathogenesis, such as the PARP inhibitor nicotinamide and the antioxidant melatonin, have shown promising results in ameliorating functional deficits and biochemical alterations associated with DN. This review aims to understanding the interplay between oxidative stress and inflammation and further exploration of natural products and synthesized small molecules as potential therapeutic agents for DN management.
Description
This article was originally published in Annals of Multidisciplinary Research, Innovation and Technology. The version of record is available at: https://adtu.in/files/current_issue/vol3_issue1/vol3-issue1-article003.pdf
Keywords
Diabetic neuropathy (DN), Oxidative Stress, Inflammation, Natural products, good health and well-being
Citation
Samanta, Suman Kumar, Dhritismita Deka, Raghuram Kandimalla, Aparajita Ghosh, Sagar Ramrao Barge, Bhaswati Kashyap, Simanta Bharadwaj, and Narayan Chandra Talukdar. “Emerging Natural and Synthetic Compounds in the Management of Diabetic Neuropathy: Targeting Oxidative Stress and Inflammation,” Annals of Multidisciplinary Research, Innovation and Technology (AMRIT), 3(1), 15-22, 2024.