The Significance of Aldehyde Dehydrogenase 1 in Cancers

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dc.contributor.authorNguyen, Anh L.
dc.contributor.authorFacey, Caroline O. B.
dc.contributor.authorBoman, Bruce M.
dc.date.accessioned2025-01-09T20:02:48Z
dc.date.available2025-01-09T20:02:48Z
dc.date.issued2024-12-30
dc.descriptionThis article was originally published in International Journal of Molecular Sciences. The version of record is available at: https://doi.org/10.3390/ijms26010251. © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.description.abstractThe goal of this paper is to discuss the role of ALDH isozymes in different cancers, review advances in ALDH1-targeting cancer therapies, and explore a mechanism that explains how ALDH expression becomes elevated during cancer development. ALDH is often overexpressed in cancer, and each isoform has a unique expression pattern and a distinct role in different cancers. The abnormal expression of ALDHs in different cancer types (breast, colorectal, lung, gastric, cervical, melanoma, prostate, and renal) is presented and correlated with patient prognosis. ALDH plays a significant role in various cellular functions, such as metabolism, oxidative stress response, detoxification, and cellular differentiation. Among the ALDH families, ALDH1 has gained considerable attention as a cancer stem cell (CSC) marker due to its significant role in the maintenance of stemness and the differentiation of stem cells (SCs), along with its involvement in tumorigenesis. A description of the cellular mechanisms and physiology of ALDH1 that underlies cancer development is provided. Moreover, current advances in ALDH1-targeting cancer therapies are discussed.
dc.description.sponsorshipGenerous support was provided by the Lisa Dean Moseley Foundation for stem cell research.
dc.identifier.citationNguyen, Anh L., Caroline O. B. Facey, and Bruce M. Boman. 2025. "The Significance of Aldehyde Dehydrogenase 1 in Cancers" International Journal of Molecular Sciences 26, no. 1: 251. https://doi.org/10.3390/ijms26010251
dc.identifier.issn1422-0067
dc.identifier.urihttps://udspace.udel.edu/handle/19716/35703
dc.language.isoen_US
dc.publisherInternational Journal of Molecular Sciences
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectaldehyde dehydrogenase
dc.subjectALDH isoenzymes
dc.subjectretinoic acid
dc.subjectcancer stem cells
dc.subjectcolorectal cancer
dc.subjectbreast cancer
dc.subjectlung cancer
dc.subjectgastric cancer
dc.subjectcervical cancer
dc.subjectmelanoma
dc.subjectprostate cancer
dc.subjectrenal cancer
dc.titleThe Significance of Aldehyde Dehydrogenase 1 in Cancers
dc.typeArticle

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