The Significance of Aldehyde Dehydrogenase 1 in Cancers
Date
2024-12-30
Journal Title
Journal ISSN
Volume Title
Publisher
International Journal of Molecular Sciences
Abstract
The goal of this paper is to discuss the role of ALDH isozymes in different cancers, review advances in ALDH1-targeting cancer therapies, and explore a mechanism that explains how ALDH expression becomes elevated during cancer development. ALDH is often overexpressed in cancer, and each isoform has a unique expression pattern and a distinct role in different cancers. The abnormal expression of ALDHs in different cancer types (breast, colorectal, lung, gastric, cervical, melanoma, prostate, and renal) is presented and correlated with patient prognosis. ALDH plays a significant role in various cellular functions, such as metabolism, oxidative stress response, detoxification, and cellular differentiation. Among the ALDH families, ALDH1 has gained considerable attention as a cancer stem cell (CSC) marker due to its significant role in the maintenance of stemness and the differentiation of stem cells (SCs), along with its involvement in tumorigenesis. A description of the cellular mechanisms and physiology of ALDH1 that underlies cancer development is provided. Moreover, current advances in ALDH1-targeting cancer therapies are discussed.
Description
This article was originally published in International Journal of Molecular Sciences. The version of record is available at: https://doi.org/10.3390/ijms26010251.
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Keywords
aldehyde dehydrogenase, ALDH isoenzymes, retinoic acid, cancer stem cells, colorectal cancer, breast cancer, lung cancer, gastric cancer, cervical cancer, melanoma, prostate cancer, renal cancer
Citation
Nguyen, Anh L., Caroline O. B. Facey, and Bruce M. Boman. 2025. "The Significance of Aldehyde Dehydrogenase 1 in Cancers" International Journal of Molecular Sciences 26, no. 1: 251. https://doi.org/10.3390/ijms26010251