Deciphering the Neural Effects of Emotional, Motivational, and Cognitive Challenges on Inhibitory Control Processes
| Author(s) | Bounoua, Nadia | |
| Author(s) | Stumps, Anna | |
| Author(s) | Church, Leah | |
| Author(s) | Spielberg, Jeffrey M. | |
| Author(s) | Sadeh, Naomi | |
| Date Accessioned | 2025-02-03T20:32:58Z | |
| Date Available | 2025-02-03T20:32:58Z | |
| Publication Date | 2025-01-24 | |
| Description | This article was originally published in Human Brain Mapping. The version of record is available at: https://doi.org/10.1002/hbm.70137. © 2025 The Author(s). Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | |
| Abstract | Converging lines of research indicate that inhibitory control is likely to be compromised in contexts that place competing demands on emotional, motivational, and cognitive systems, potentially leading to damaging impulsive behavior. The objective of this study was to identify the neural impact of three challenging contexts that typically compromise self-regulation and weaken impulse control. Participants included 66 healthy adults (M/SDage = 29.82/10.21 years old, 63.6% female) who were free of psychiatric disorders and psychotropic medication use. Participants completed a set of novel Go/NoGo (GNG) paradigms in the scanner, which manipulated contextual factors to induce (i) aversive emotions, (ii) appetitive drive, or (iii) concurrent working memory load. Voxelwise analysis of neural activation during each of these tasks was compared to that of a neutral GNG task. Findings revealed differential inhibition-related activation in the aversive emotions and appetitive drive GNG tasks relative to the neutral task in frontal, parietal and temporal cortices, suggesting emotional and motivational contexts may suppress activation of these cortical regions during inhibitory control. In contrast, the GNG task with a concurrent working memory load showed widespread increased activation across the cortex compared to the neutral task, indicative of enhanced recruitment of executive control regions. Results suggest the neural circuitry recruited for inhibitory control varies depending on the concomitant emotional, motivational, and cognitive demands of a given context. This battery of GNG tasks can be used by researchers interested in studying unique patterns of neural activation associated with inhibitory control across three clinically relevant contexts that challenge self-regulation and confer risk for impulsive behavior. Summary - Examining the impact of context on the neural mechanisms supporting inhibitory control is critical for furthering the field's understanding of self-regulation. - This study assessed the utility of three new fMRI Go/NoGo tasks for examining how emotional, motivational, and cognitive contexts influence the neural circuits involved in inhibitory control. - Results revealed differential recruitment of inhibitory control-related brain regions depending on contextual demands, underscoring the utility of examining inhibitory control across challenging contexts using these novel Go/NoGo fMRI tasks. | |
| Sponsor | This work was supported by the National Institute of Mental Health (1R01MH116228 awarded to NS; 1F31MH120936 awarded to NB; F31MH135695-01A1 awarded to AS) and National Institute of General Medical Sciences (2P20GM103653 awarded to NS). It was also supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences (P30GM145765). | |
| Citation | Bounoua, N., Stumps, A., Church, L., Spielberg, J.M. and Sadeh, N. (2025), Deciphering the Neural Effects of Emotional, Motivational, and Cognitive Challenges on Inhibitory Control Processes. Hum Brain Mapp, 46: e70137. https://doi.org/10.1002/hbm.70137 | |
| ISSN | 1097-0193 | |
| URL | https://udspace.udel.edu/handle/19716/35785 | |
| Language | en_US | |
| Publisher | Human Brain Mapping | |
| dc.rights | Attribution-NonCommercial 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | |
| Keywords | fMRI | |
| Keywords | impulsivity | |
| Keywords | negative mood | |
| Keywords | reward | |
| Keywords | self-regulation | |
| Keywords | working memory | |
| Title | Deciphering the Neural Effects of Emotional, Motivational, and Cognitive Challenges on Inhibitory Control Processes | |
| Type | Article |
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