YAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disorders

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Author(s)Ajongbolo, Aderonke O.
Author(s)Langhans, Sigrid A.
Date Accessioned2025-01-30T17:58:25Z
Date Available2025-01-30T17:58:25Z
Publication Date2025-01-28
DescriptionThis article was originally published in Frontiers in Cell and Developmental Biology by Frontiers Media. The version of record is available at: https://doi.org/10.3389/fcell.2025.1522705. © 2025 Ajongbolo and Langhans. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
AbstractYAP/TAZ (Yes-associated protein/paralog transcriptional co-activator with PDZ-binding domain) are transcriptional cofactors that are the key and major downstream effectors of the Hippo signaling pathway. Both are known to play a crucial role in defining cellular outcomes, including cell differentiation, cell proliferation, and apoptosis. Aside from the canonical Hippo signaling cascade with the key components MST1/2 (mammalian STE20-like kinase 1/2), SAV1 (Salvador homologue 1), MOB1A/B (Mps one binder kinase activator 1A/B) and LATS1/2 (large tumor suppressor kinase 1/2) upstream of YAP/TAZ, YAP/TAZ activation is also influenced by numerous other signaling pathways. Such non-canonical regulation of YAP/TAZ includes well-known growth factor signaling pathways such as the epidermal growth factor receptor (EGFR)/ErbB family, Notch, and Wnt signaling as well as cell-cell adhesion, cell-matrix interactions and mechanical cues from a cell’s microenvironment. This puts YAP/TAZ at the center of a complex signaling network capable of regulating developmental processes and tissue regeneration. On the other hand, dysregulation of YAP/TAZ signaling has been implicated in numerous diseases including various cancers and neurodevelopmental disorders. Indeed, in recent years, parallels between cancer development and neurodevelopmental disorders have become apparent with YAP/TAZ signaling being one of these pathways. This review discusses the role of YAP/TAZ in brain development, cancer and neurodevelopmental disorders with a special focus on the interconnection in the role of YAP/TAZ in these different conditions.
SponsorThe author(s) declare that financial support was received for the research, authorship, and/or publication of this article. Support was provided by National Institutes of Health grant R01 CA263216 and the Nemours Foundation. This study was further supported by a supplement to a Center of Biomedical Research Excellence (COBRE) award from the National Institute of General Medical Science of the National Institutes of Health under grant number P30GM145765.
CitationAjongbolo AO and Langhans SA (2025) YAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disorders. Front. Cell Dev. Biol. 13:1522705. doi: 10.3389/fcell.2025.1522705
ISSN2296-634X
URLhttps://udspace.udel.edu/handle/19716/35768
Languageen_US
PublisherFrontiers in Cell and Developmental Biology
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
Keywordshippo
Keywordsbrain
Keywordscancer
Keywordsneurodevelopmental disorder
Keywordsmicroenvironment
KeywordsYAP/TAZ signaling
TitleYAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disorders
TypeArticle
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