Using deep learning to classify developmental differences in reaching and placing movements in children with and without autism spectrum disorder
| Author(s) | Su, Wan-Chun | |
| Author(s) | Mutersbaugh, John | |
| Author(s) | Huang, Wei-Lun | |
| Author(s) | Bhat, Anjana | |
| Author(s) | Gandjbakhche, Amir | |
| Date Accessioned | 2024-12-20T20:00:29Z | |
| Date Available | 2024-12-20T20:00:29Z | |
| Publication Date | 2024-12-05 | |
| Description | This article was originally published in Scientific Reports. The version of record is available at: https://doi.org/10.1038/s41598-024-81652-z. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024. | |
| Abstract | Autism Spectrum Disorder (ASD) is among the most prevalent neurodevelopmental disorders, yet the current diagnostic procedures rely on behavioral analyses and interviews, without objective screening methods to support the diagnostic process. This study seeks to address this gap by integrating upper limb kinematics and deep learning methods to identify potential biomarkers that could be validated in younger age groups in the future to enhance the identification of ASD. Forty-one school-age children, with and without an ASD diagnosis (mean age ± SE: TD group: 10.3 ± 0.8, 8 males and 7 females; ASD group: 10.3 ± 0.5, 21 males and 5 females), participated in the study. A single Inertial Measurement Unit (IMU) was affixed to the child’s wrist as they engaged in a continuous reaching and placing task. Deep learning techniques were employed to classify children with and without ASD. Our findings suggest differential movement kinematics in school-age children compared to healthy adults. Compared to TD children, children with ASD exhibited poor feedforward/feedback control of arm movements as seen by greater number of movement units, more movement overshooting, and prolonged time to peak velocity/acceleration. Unique movement strategies such as greater velocity and acceleration were also seen in the ASD group. More importantly, using Multilayer Perceptron (MLP) model, we demonstrated an accuracy of ~ 78.1% in classifying children with and without ASD. These findings underscore the potential use of studying upper limb movement kinematics during goal-directed arm movements and deep learning methods as valuable tools for classifying and, consequently, aiding in the diagnosis and early identification of ASD upon further validation of their specificity among younger children. | |
| Sponsor | Acknowledgements This study was supported by the Intramural Research Program (IRP) of the National Institute of Child Health and Human Development (Project Number: 1ZIAHD008882-10), the National Institute of Health’s Bench-to-Bedside Program, the National Institutes of Health through a shared instrumentation grant awarded to the University of Delaware (Grant #: 1S10OD021534-01, PI: Bhat), pilot award funding through an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health (U54-GM104941, PI: Binder-Macleod; P20 GM103446, PI: Stanhope) and funding from the Dana Foundation through a Clinical Neuroscience Award (PI: Bhat). Funding Open access funding provided by the National Institutes of Health | |
| Citation | Su, WC., Mutersbaugh, J., Huang, WL. et al. Using deep learning to classify developmental differences in reaching and placing movements in children with and without autism spectrum disorder. Sci Rep 14, 30283 (2024). https://doi.org/10.1038/s41598-024-81652-z | |
| ISSN | 2045-2322 | |
| URL | https://udspace.udel.edu/handle/19716/35678 | |
| Language | en_US | |
| Publisher | Scientific Reports | |
| dc.rights | Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| Keywords | motor control | |
| Keywords | neuroscience | |
| Keywords | sensorimotor processing | |
| Keywords | signs and symptoms | |
| Title | Using deep learning to classify developmental differences in reaching and placing movements in children with and without autism spectrum disorder | |
| Type | Article |
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