Associations between Brain Alpha-Tocopherol Stereoisomer Profile and Hallmarks of Brain Aging in Centenarians

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Author(s)Chan, Jia Pei
Author(s)Tanprasertsuk, Jirayu
Author(s)Johnson, Elizabeth J.
Author(s)Dey, Priyankar
Author(s)Bruno, Richard S.
Author(s)Johnson, Mary Ann
Author(s)Poon, Leonard W.
Author(s)Davey, Adam
Author(s)Woodard, John L.
Author(s)Kuchan, Matthew J.
Date Accessioned2024-09-05T15:57:01Z
Date Available2024-09-05T15:57:01Z
Publication Date2024-08-17
DescriptionThis article was originally published in Antioxidants. The version of record is available at: https://doi.org/10.3390/antiox13080997 © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
AbstractBrain alpha-tocopherol (αT) concentration was previously reported to be inversely associated with neurofibrillary tangle (NFT) counts in specific brain structures from centenarians. However, the contribution of natural or synthetic αT stereoisomers to this relationship is unknown. In this study, αT stereoisomers were quantified in the temporal cortex (TC) of 47 centenarians in the Georgia Centenarian Study (age: 102.2 ± 2.5 years, BMI: 22.1 ± 3.9 kg/m2) and then correlated with amyloid plaques (diffuse and neuritic plaques; DPs, NPs) and NFTs in seven brain regions. The natural stereoisomer, RRR-αT, was the primary stereoisomer in all subjects, accounting for >50% of total αT in all but five subjects. %RRR was inversely correlated with DPs in the frontal cortex (FC) (ρ = −0.35, p = 0.032) and TC (ρ = −0.34, p = 0.038). %RSS (a synthetic αT stereoisomer) was positively correlated with DPs in the TC (ρ = 0.39, p = 0.017) and with NFTs in the FC (ρ = 0.37, p = 0.024), TC (ρ = 0.42, p = 0.009), and amygdala (ρ = 0.43, p = 0.008) after controlling for covariates. Neither RRR- nor RSS-αT were associated with premortem global cognition. Even with the narrow and normal range of BMIs, BMI was correlated with %RRR-αT (ρ = 0.34, p = 0.021) and %RSS-αT (ρ = −0.45, p = 0.002). These results providing the first characterization of TC αT stereoisomer profiles in centenarians suggest that DP and NFT counts, but not premortem global cognition, are influenced by the brain accumulation of specific αT stereoisomers. Further study is needed to confirm these findings and to determine the potential role of BMI in mediating this relationship.
SponsorThis research and APC were funded by Abbott Nutrition (no grant number available).
CitationChan, Jia Pei, Jirayu Tanprasertsuk, Elizabeth J. Johnson, Priyankar Dey, Richard S. Bruno, Mary Ann Johnson, Leonard W. Poon, Adam Davey, John L. Woodard, and Matthew J. Kuchan. 2024. "Associations between Brain Alpha-Tocopherol Stereoisomer Profile and Hallmarks of Brain Aging in Centenarians" Antioxidants 13, no. 8: 997. https://doi.org/10.3390/antiox13080997
ISSN2076-3921
URLhttps://udspace.udel.edu/handle/19716/34913
Languageen_US
PublisherAntioxidants
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
Keywordsvitamin E
Keywordstocopherol
Keywordsbrain
Keywordscognition
Keywordsaging
Keywordsneurofibrillary tangle
Keywordsamyloid plaque
Keywordsolder adult
Keywordscentenarian
TitleAssociations between Brain Alpha-Tocopherol Stereoisomer Profile and Hallmarks of Brain Aging in Centenarians
TypeArticle
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