A Mathematical Model Of The Human External Respiratory System

Dantzig, George B.
DeHaven, James C.
Cooper, Irwin
Johnson, Selmar M.
DeLand, Edward C.
Kanter, Herschel
Sams, Crawford F. M.D.
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Rand Corporation
This study examines the thesis that a part of the human physiological system can be simulated by a suitably constructed mathematical model. The model employed derives from a class of mathematical programming methods that were originally developed for representing complex military and industrial activities and have recently been used to represent involved chemical equilibria. The motivation for this research is the long-range view that a successful mathematical simulation of the human system or of human subsystems would provide an important tool for biological investigations. A sufficiently complex mathematical model-that is, a model that embodies sufficiently complex mathematical model-that is, a model that embodies sufficient chemical and biological detail to represent a whole, functioning human system or subsystem-could be used to explore biological hypotheses, environmental stress reactions, and interplay of dependent subsystems, and could serve as a pedagogical tool or even as an aid to medical diagnosis. Of course, the foregoing long-range view is an ultimate goal. For the moment, only the techniques, concepts, and characteristics of such a mathematical model are being explored. This paper presents the results of a simulation of the external respiratory function. Respiration, and the consequent gas exchanges at the lung surfaces, involves many chemical reactions and a transformation of venous blood into arterial blood. This activity was chosen as a test cast to explore the feasibility of constructing a mathematical model of a human subsystem.
Mathematical Model , Respiratory System