Hypoplastic left heart syndrome: Component models for cardiovascular systems after the Norwood procedure

Date
2013
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University of Delaware
Abstract
The goal of the Norwood procedure is to provide systemic circulation in a cardiovascular system with a single ventricle. This procedure is universally performed on the patient population of newborns with a underdeveloped left ventricle, Hypoplastic Left Heart Syndrome (HLHS). Two alternative surgical methods are employed to provide the pulmonary circulation, Right Ventricle-Pulmonary Artery Conduit method and the Blalock-Taussig Shunt method. The objective of this study is to take a previous compartment model of the two cardiovascular systems, verify the physiology and accuracy of the system of ordinary differential equations, implement a simulator based on the mathematical model, and evaluate the model's capacity to produce a realistic right ventricular pressure-volume loop. A MATLAB based software tool was written to model both procedures and provide a graphical user interface for others in clinical practice. An optimizer was used to adjust the parameters in order to produce a pressure-volume loop comparable to expectations. Once a reasonable P-V loop was obtained for each model, the physiological realism of the model was analyzed to discover its validity and limitations.
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